Target Details

Name:	Phosphatidylinositol 3-kinase regulatory subunit alpha
Uniprot name:	P85A_HUMAN
Accession Numbers:	P27986 Q15747 Q4VBZ7 Q53EM6 Q8IXA2 Q8N1C5
EC-Number:	-
Organism:	Homo sapiens Human
PDB IDs:	1A0N 1AZG 1H9O 1PBW 1PHT 1PIC 1PKS 1PKT 2IUG 2IUH 2IUI 2RD0 2V1Y
KEGG Pathways:	show KEGG Pathways
Drugs:	Name PubChem ID Source References Interaction akt inhibitor 16760281 BindingDB - show CHEMBL112635 44340565 BindingDB - show CHEMBL112884 44340507 BindingDB - show CHEMBL205591 44410753 BindingDB - show CHEMBL208279 44410748 BindingDB - show CHEMBL300015 44294776 BindingDB - show CHEMBL301619 44294628 BindingDB - show CHEMBL381040 44410755 BindingDB - show CHEMBL382875 44410752 BindingDB - show CHEMBL383037 44410598 BindingDB - show CHEMBL383415 44410756 BindingDB - show CHEMBL48761 44294975 BindingDB - show CHEMBL51940 44294629 BindingDB - show CHEMBL51941 44294630 BindingDB - show CHEMBL52389 44294775 BindingDB - show CHEMBL97733 44340502 BindingDB - show Dihydroxyphenylethanolisopropylamine 3779 DrugBank - show JNK Inhibitor V 11422035 BindingDB - show wortmannin 312145 BindingDB - show Wortmannin from Penicillium funiculosum 3003565 BindingDB - show enlarge table
Synonyms:	Phosphatidylinositol 3-kinase regulatory subunit alpha PI3-kinase p85 subunit alpha PI3K PtdIns-3-kinase p85-alpha enlarge table
Similar targets:	Uniprot name % Sequence similarity % Sequence identity IKKB_HUMAN 33.1 17.5 IKKA_HUMAN 31.8 17 IKKE_HUMAN 31.1 19.3 RAD50_PYRFU 30.9 17.1 ECHA_HUMAN 30.6 17.2 KINH_HUMAN 30.4 14.1 Q7VFP2_HELHP 30.3 15.9 RAF1_RAT 30.3 17.1 GCYA2_HUMAN 30.1 15.8 PUR9_CHICK 30 18.4 CTNB1_MOUSE 29.7 15.8 KIF2C_MOUSE 29.7 17.2 CTNB1_HUMAN 29.7 15.8 RFCS_PYRFU 29.3 17.4 VCAM1_HUMAN 29.3 15.6 GYRA_ECOLI 29.2 15.5 Q96QW8_HUMAN 29.2 15.5 PDE4A_HUMAN 29.1 18 DCE1_HUMAN 29.1 15 TRXR1_MOUSE 29.1 17.1 RPGP1_HUMAN 29 16.3 NANH_VIBCH 28.9 16.7 Q53688_9CREN 28.9 15.3 TYRO_NEUCR 28.9 17 NCD_DROME 28.9 16 ATGT_PYRHO 28.9 16 MCE1_MOUSE 28.9 16.6 Q8IVA8_HUMAN 28.9 14.9 Q7SIA3_MARHY 28.8 14.8 PLD1_HUMAN 28.6 16.8 enlarge table
Protein-Protein Interactions:	Uniprot name Source WBP11_HUMAN PMID 11375989 WASP_HUMAN 2 PMIDs WASF3_HUMAN 3 PMIDs VP13A_HUMAN 4 PMIDs VGFR1_HUMAN 5 PMIDs VAV_HUMAN 6 PMIDs VAV_HUMAN 7 PMIDs VAV3_HUMAN 8 PMIDs UFO_HUMAN 9 PMIDs UB7I3_HUMAN 10 PMIDs TYRO3_HUMAN 11 PMIDs TYK2_HUMAN 12 PMIDs TULP4_HUMAN 13 PMIDs TUB_HUMAN 14 PMIDs TSHR_HUMAN 15 PMIDs TRYB2_HUMAN 16 PMIDs TRYB1_HUMAN 17 PMIDs TRYA1_HUMAN 18 PMIDs TRAT1_HUMAN 19 PMIDs TPX2_HUMAN 20 PMIDs TNR5_HUMAN 21 PMIDs TNFL6_HUMAN 22 PMIDs TM1L1_HUMAN 23 PMIDs TLR3_HUMAN 24 PMIDs TLR2_HUMAN 25 PMIDs TLN1_HUMAN 26 PMIDs TIE2_HUMAN 27 PMIDs TIE1_HUMAN 28 PMIDs TGON2_HUMAN 29 PMIDs TGFR2_HUMAN 30 PMIDs TGFR1_HUMAN 31 PMIDs TGDS_HUMAN 32 PMIDs TEC_HUMAN 33 PMIDs TBG1_HUMAN 34 PMIDs TBA1B_HUMAN 35 PMIDs SYNJ2_HUMAN 36 PMIDs SYN1_HUMAN 37 PMIDs SYDC_HUMAN 38 PMIDs SUV92_HUMAN 39 PMIDs STF1_HUMAN 40 PMIDs SSR2_HUMAN 41 PMIDs SOS2_HUMAN 42 PMIDs SOS1_HUMAN 43 PMIDs SOCS7_HUMAN 44 PMIDs SOCS6_HUMAN 45 PMIDs SOCS6_HUMAN 46 PMIDs SOCS1_HUMAN 47 PMIDs SNX8_HUMAN 48 PMIDs SNX17_HUMAN 49 PMIDs SHC1_HUMAN 50 PMIDs SHC1_HUMAN 51 PMIDs SHC1_HUMAN 52 PMIDs SHB_HUMAN 53 PMIDs SHAN3_HUMAN 54 PMIDs SHAN2_HUMAN 55 PMIDs SH3K1_HUMAN 56 PMIDs SEPT2_HUMAN 57 PMIDs SCG2_HUMAN 58 PMIDs S23A1_HUMAN 59 PMIDs RRAS_HUMAN 60 PMIDs RRAS2_HUMAN 61 PMIDs RPGF1_HUMAN 62 PMIDs RON_HUMAN 63 PMIDs RL13_HUMAN 64 PMIDs RICS_HUMAN 65 PMIDs RHG17_HUMAN 66 PMIDs RHG01_HUMAN 67 PMIDs RET_HUMAN 68 PMIDs RASH_HUMAN 69 PMIDs RASE_HUMAN 70 PMIDs RASA1_HUMAN 71 PMIDs RASA1_HUMAN 72 PMIDs RAC1_HUMAN 73 PMIDs Q13746_HUMAN 74 PMIDs PTN4_HUMAN 75 PMIDs PSN1_HUMAN 76 PMIDs PSB5_HUMAN 77 PMIDs PROF1_HUMAN 78 PMIDs PPM1A_HUMAN 79 PMIDs PLCG2_HUMAN 80 PMIDs PK3CG_HUMAN 80 PMIDs PK3CD_HUMAN 81 PMIDs PK3CD_HUMAN 81 PMIDs PK3CB_HUMAN 82 PMIDs PK3CB_HUMAN 82 PMIDs PK3CA_HUMAN 83 PMIDs PK3CA_HUMAN 83 PMIDs PHAR2_HUMAN 84 PMIDs PGFRB_HUMAN 85 PMIDs PGFRB_HUMAN 86 PMIDs PGFRA_HUMAN 87 PMIDs PERE_HUMAN 88 PMIDs PEBP1_HUMAN 89 PMIDs PDIA2_HUMAN 90 PMIDs PCBP2_HUMAN 91 PMIDs PAXI_HUMAN 92 PMIDs P85B_HUMAN 93 PMIDs P85A_HUMAN 94 PMIDs P55G_HUMAN 95 PMIDs P3C2B_HUMAN 96 PMIDs NUT_HUMAN 97 PMIDs NUP85_HUMAN 98 PMIDs NTRK2_HUMAN 99 PMIDs NTRK1_HUMAN 100 PMIDs NFKB1_HUMAN 101 PMIDs NEP_HUMAN 102 PMIDs NELFB_HUMAN 103 PMIDs NCKX1_HUMAN 104 PMIDs MYRIP_HUMAN 105 PMIDs MYLK_HUMAN 106 PMIDs MK08_HUMAN 107 PMIDs MINT_HUMAN 108 PMIDs MET_HUMAN 109 PMIDs MEPE_HUMAN 110 PMIDs MED28_HUMAN 110 PMIDs MAP4_HUMAN 111 PMIDs M4K1_HUMAN 112 PMIDs LTK_HUMAN 113 PMIDs LIPA3_HUMAN 114 PMIDs LCP2_HUMAN 115 PMIDs LAT_HUMAN 116 PMIDs KSYK_HUMAN 117 PMIDs KSYK_HUMAN 118 PMIDs KIT_HUMAN 119 PMIDs KI13A_HUMAN 120 PMIDs KHDR1_HUMAN 121 PMIDs KHDR1_HUMAN 122 PMIDs JAK3_HUMAN 123 PMIDs JAK2_HUMAN 124 PMIDs JAK1_HUMAN 125 PMIDs IRS4_HUMAN 126 PMIDs IRS2_HUMAN 127 PMIDs IRS1_HUMAN 128 PMIDs INS_HUMAN 129 PMIDs INSR_HUMAN 130 PMIDs INP4A_HUMAN 131 PMIDs INAR1_HUMAN 132 PMIDs IL7RA_HUMAN 133 PMIDs IL6RB_HUMAN 134 PMIDs IL2RB_HUMAN 135 PMIDs IL1R1_HUMAN 136 PMIDs IL1AP_HUMAN 137 PMIDs IL13_HUMAN 138 PMIDs IKBA_HUMAN 139 PMIDs IGF1R_HUMAN 140 PMIDs ID4_HUMAN 141 PMIDs ICAL_HUMAN 142 PMIDs HNRPK_HUMAN 143 PMIDs HGS_HUMAN 144 PMIDs HCST_HUMAN 145 PMIDs HCK_HUMAN 146 PMIDs GSCR1_HUMAN 147 PMIDs GHR_HUMAN 148 PMIDs GBRA3_HUMAN 149 PMIDs GABR1_HUMAN 150 PMIDs GAB3_HUMAN 151 PMIDs GAB2_HUMAN 152 PMIDs FOXH1_HUMAN 153 PMIDs FLNC_HUMAN 154 PMIDs FLNB_HUMAN 155 PMIDs FLNA_HUMAN 156 PMIDs FGFR2_HUMAN 157 PMIDs FGFR1_HUMAN 158 PMIDs FES_HUMAN 159 PMIDs FCG2A_HUMAN 160 PMIDs FANCA_HUMAN 161 PMIDs FAK2_HUMAN 162 PMIDs FAK1_HUMAN 163 PMIDs EZRI_HUMAN 164 PMIDs EXTL3_HUMAN 165 PMIDs ESR1_HUMAN 166 PMIDs ERBB3_HUMAN 167 PMIDs ERBB3_HUMAN 168 PMIDs ERBB2_HUMAN 169 PMIDs ERBB2_HUMAN 170 PMIDs ERBB2_HUMAN 171 PMIDs EPOR_HUMAN 172 PMIDs EPHA2_HUMAN 173 PMIDs ELK3_HUMAN 174 PMIDs EGFR_HUMAN 175 PMIDs EGFR_HUMAN 176 PMIDs EGFR_HUMAN 177 PMIDs EFS_HUMAN 178 PMIDs ECT2_HUMAN 179 PMIDs DYN1_HUMAN 180 PMIDs DUS15_HUMAN 181 PMIDs DTBP1_HUMAN 182 PMIDs DOK1_HUMAN 183 PMIDs DOCK3_HUMAN 184 PMIDs DNLI3_HUMAN 185 PMIDs DLX4_HUMAN 186 PMIDs DLGP4_HUMAN 187 PMIDs DLGP3_HUMAN 188 PMIDs DLGP2_HUMAN 189 PMIDs DLGP1_HUMAN 190 PMIDs DAG1_HUMAN 191 PMIDs DAB2_HUMAN 192 PMIDs CTNB1_HUMAN 193 PMIDs CTLA4_HUMAN 194 PMIDs CSF2R_HUMAN 195 PMIDs CSF1R_HUMAN 196 PMIDs CSDE1_HUMAN 197 PMIDs CSDC2_HUMAN 198 PMIDs CRK_HUMAN 199 PMIDs CRKL_HUMAN 200 PMIDs CKAP5_HUMAN 201 PMIDs CDC42_HUMAN 202 PMIDs CD7_HUMAN 203 PMIDs CD5_HUMAN 204 PMIDs CD4_HUMAN 205 PMIDs CD3E_HUMAN 206 PMIDs CD2AP_HUMAN 207 PMIDs CD28_HUMAN 208 PMIDs CD22_HUMAN 209 PMIDs CD19_HUMAN 210 PMIDs CD19_HUMAN 211 PMIDs CCNT1_HUMAN 212 PMIDs CBL_HUMAN 213 PMIDs CBL_HUMAN 214 PMIDs CBLB_HUMAN 215 PMIDs CAF1A_HUMAN 216 PMIDs CADH2_HUMAN 217 PMIDs BRPF3_HUMAN 218 PMIDs BRD4_HUMAN 219 PMIDs BRCA1_HUMAN 220 PMIDs BCAR1_HUMAN 221 PMIDs BCAP_HUMAN 222 PMIDs ASAP2_HUMAN 223 PMIDs ASAP1_HUMAN 224 PMIDs ARHGB_HUMAN 225 PMIDs ARAF_HUMAN 226 PMIDs APOL5_HUMAN 227 PMIDs ANK3_HUMAN 228 PMIDs AL2SB_HUMAN 229 PMIDs AKAP6_HUMAN 230 PMIDs AKAP2_HUMAN 231 PMIDs AIRE_HUMAN 232 PMIDs AGAP2_HUMAN 233 PMIDs ADA12_HUMAN 234 PMIDs ACHA7_HUMAN 235 PMIDs ABL2_HUMAN 236 PMIDs ABL1_HUMAN 237 PMIDs ABCG5_HUMAN 238 PMIDs 1433G_HUMAN 239 PMIDs enlarge table

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