Target Details

Name:	5-methyltetrahydrofolate--homocysteine methyltransferase
Uniprot name:	METH_HUMAN
Accession Numbers:	A1L4N8 A9Z1W4 B9EGF7 Q99707 Q99713 Q99723
EC-Number:	2.1.1.13
Organism:	Homo sapiens Human
PDB IDs:	2O2K
KEGG Pathways:	show KEGG Pathways
Drugs:	Name PubChem ID Source References Interaction Cyanocobalamin 5462245 SuperTarget - show Hydroxocobalamin 11953898 DrugBank - show Hydroxocobalamin 11953898 SuperTarget - show Mononitrogen monoxide 945 SuperTarget PMID 7941962 show Polymethionine 6137 DrugBank - show Polymethionine 6137 SuperTarget - show Tetrahydropteroylglutamate 91443 DrugBank - show Tetrahydropteroylglutamate 1129 DrugBank - show enlarge table
Synonyms:	5-methyltetrahydrofolate--homocysteine methyltransferase Methionine synthase MS Vitamin-B12 dependent methionine synthase enlarge table
Similar targets:	Uniprot name % Sequence similarity % Sequence identity METH_ECOLI 67.9 53.1 Q9WYA5_THEMA 33.5 20.3 EGFR_HUMAN 29.5 17 PYC_HUMAN 28.7 16.4 VGFR2_HUMAN 28.4 16.9 POL_HV1N5 28.4 16.1 IDE_HUMAN 28.2 16.1 PUR4_HUMAN 28.2 17.6 POL_HV1A2 28.1 16.3 EGFR_MOUSE 28 15.9 JAK3_HUMAN 28 16.9 TOP2A_RAT 27.9 15.6 NCOA2_HUMAN 27.9 16.5 CY41_TRYBB 27.7 15.8 HYSA_STRA3 27.6 16 ROCK1_HUMAN 27.5 15.8 PARP1_RAT 27.5 15.5 O57480_CHICK 27.4 16.1 POL_HV1B1 27.4 16.4 PARP1_MOUSE 27.3 14.9 RPOB_ECOLI 27.3 16.2 AT12A_HUMAN 27.3 15.8 OGA_CLOPE 27.2 15.3 POL_HV1Y2 27.2 16.5 POL_HV1H2 27.2 16.4 DPOL_EBVB9 27 15.5 DAPK1_HUMAN 26.7 15.8 NOS1_MOUSE 26.7 15.6 ADCY2_RAT 26.7 15.1 A2MG_HUMAN 26.6 16.1 enlarge table
Protein-Protein Interactions:	Uniprot name Source T22D1_HUMAN PMID 17145710,17353931 enlarge table

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