Target Details

Name:

cAMP-dependent protein kinase catalytic subunit alpha

Uniprot name:

KAPCA_MOUSE

Accession Numbers:

P05132 Q9JID0

EC-Number:

2.7.11.11

Organism:

Mouse
Mus musculus

PDB IDs:

1APM 1ATP 1BKX 1BX6 1FMO 1J3H 1JBP 1JLU 1L3R 1PVK 1RDQ 1RE8 1REJ 1REK 1SYK 2CPK 2ERZ 2QCS 2QUR 2QVS 3FHI 3FJQ

KEGG Pathways:

show KEGG Pathways

Drugs:

Name	PubChem ID	Source	References	Interaction
()-oxazepam hemisuccinate sodium salt	25190768	BindingDB	-	show
()-oxazepam hemisuccinate sodium salt	25190769	BindingDB	-	show
()-oxazepam hemisuccinate sodium salt	25190790	BindingDB	-	show
()-oxazepam hemisuccinate sodium salt	16121514	BindingDB	-	show
()-oxazepam hemisuccinate sodium salt	25190791	BindingDB	-	show
()-oxazepam hemisuccinate sodium salt	44282246	BindingDB	-	show
()-oxazepam hemisuccinate sodium salt	44282442	BindingDB	-	show
()-oxazepam hemisuccinate sodium salt	44282443	BindingDB	-	show
()-oxazepam hemisuccinate sodium salt	44282377	BindingDB	-	show
()-oxazepam hemisuccinate sodium salt	44282232	BindingDB	-	show
()-oxazepam hemisuccinate sodium salt	44282376	BindingDB	-	show
()-oxazepam hemisuccinate sodium salt	44282430	BindingDB	-	show
()-oxazepam hemisuccinate sodium salt	44282245	BindingDB	-	show
()-oxazepam hemisuccinate sodium salt	44282233	BindingDB	-	show
()-oxazepam hemisuccinate sodium salt	44282230	BindingDB	-	show
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE	448043	BindingDB	-	show
2-METHYL-2,4-PENTANEDIOL	5288834	DrugBank	-	show
Arabinosyladenine	191	BindingDB	-	show
BALANOL	5287736	DrugBank	-	show
Balanol analog 2	5327919	DrugBank	-	show
BALANOL ANALOG 8	448327	DrugBank	-	show
CHEBI:148314	44282203	BindingDB	-	show
CHEBI:148350	44282231	BindingDB	-	show
CHEMBL178945	10185160	BindingDB	-	show
CHEMBL297394	25190767	BindingDB	-	show
CHEMBL359486	10302405	BindingDB	-	show
CHEMBL360304	10143584	BindingDB	-	show
CHEMBL368416	10163439	BindingDB	-	show
CHEMBL368895	10209082	BindingDB	-	show
CHEMBL426587	10187378	BindingDB	-	show
CHEMBL447678	25190789	BindingDB	-	show
CHEMBL449834	25190785	BindingDB	-	show
CHEMBL450179	25141061	BindingDB	-	show
CHEMBL450260	25190781	BindingDB	-	show
CHEMBL454225	25190782	BindingDB	-	show
CHEMBL465518	25190786	BindingDB	-	show
CHEMBL495088	25190784	BindingDB	-	show
CHEMBL495766	25190765	BindingDB	-	show
CHEMBL495767	25190773	BindingDB	-	show
CHEMBL496141	25190778	BindingDB	-	show
CHEMBL496365	25190772	BindingDB	-	show
CHEMBL497800	25190777	BindingDB	-	show
CHEMBL498924	25190771	BindingDB	-	show
CHEMBL500989	25190783	BindingDB	-	show
CHEMBL501706	25190766	BindingDB	-	show
CHEMBL505949	25190770	BindingDB	-	show
CHEMBL506331	25190788	BindingDB	-	show
CHEMBL509411	25190787	BindingDB	-	show
CHEMBL510221	25190779	BindingDB	-	show
CHEMBL521551	25190774	BindingDB	-	show
CHEMBL522899	25190780	BindingDB	-	show
CHEMBL523401	25190776	BindingDB	-	show
CHEMBL523738	25190775	BindingDB	-	show
Fasudil hydrochloride	3547	BindingDB	-	show
HYDROXYFASUDIL	3064778	BindingDB	-	show
HYDROXYFASUDIL	3064778	DrugBank	-	show
L-Cysteine, mercaptoethanol mixed disulfide	170018	DrugBank	-	show
Methylheptane	356	DrugBank	-	show
N-(2-(4-Bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	449241	BindingDB	-	show
N-(2-(4-Bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	449241	PROMISCUOUS	PMID 15062850	show
nchembio.95-comp18	3501	PROMISCUOUS	PMID 16248886	show
Phosphatidalserine	68841	DrugBank	-	show
PHOSPHONOTHREONINE	3246323	DrugBank	-	show
STAUROSPORINE	44259	BindingDB	-	show
staurosporine	44299148	BindingDB	-	show
Succinonitrile, bis(amino(o-aminophenylthio)methylene)-	3006531	PROMISCUOUS	PMID 11640885	show
Tetrahydrocannabinols	2977	PROMISCUOUS	PMID 9260875	show
Tetrahydrocannabinols	16078	PROMISCUOUS	PMID 9260875	show
Valerylaldehyde	8063	DrugBank	-	show
Vidarabine	6713976	BindingDB	-	show
y-27632	448042	BindingDB	-	show

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Synonyms:

cAMP-dependent protein kinase catalytic subunit alpha

PKA C-alpha

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Similar targets:

Uniprot name	% Sequence similarity	% Sequence identity
KAPCA_HUMAN	99.4	98
KAPCA_RAT	99.1	99.1
KAPCA_PIG	99.1	97.4
KAPCA_BOVIN	98.9	97.7
KAPCB_HUMAN	95.2	92
KAPCB_MOUSE	94.3	91.5
KAPCB_RAT	94.3	91.5
KAPCG_HUMAN	91.5	81.5
KAPA_YEAST	60.1	40.6
MK14_MOUSE	43	20.4
MK14_HUMAN	42.7	20.4
AKT1_MOUSE	42.7	28.7
AKT1_HUMAN	42.5	28.5
MAPK2_HUMAN	41.1	24.1
MK12_HUMAN	40.3	20.5
MAPK2_CRILO	39.9	24
MK01_HUMAN	39.1	22.4
MK01_MOUSE	39.1	22.5
MK01_RAT	39.1	22.5
Q1HBJ4_HUMAN	39.1	22.4
Q499G7_HUMAN	38.6	22.2
MP2K2_HUMAN	37.5	20.8
MP2K3_MOUSE	37.4	22.1
CDK9_HUMAN	37.4	19.4
MK03_RAT	37.1	21.7
MK03_MOUSE	37.1	21.7
MP2K2_MOUSE	37	19.8
MP2K6_MOUSE	36.7	21.7
STK6_HUMAN	36.4	21.3
PIM1_FELCA	36.4	21.4

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Protein-Protein Interactions:

No data available

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