Target Details

Name:

JAK-3

Uniprot name:

JAK3_HUMAN

Accession Numbers:

P52333 Q13259 Q13260 Q13611 Q99699 Q9Y6S2

EC-Number:

2.7.10.2

Organism:

Homo sapiens
Human

PDB IDs:

1YVJ

KEGG Pathways:

show KEGG Pathways

Drugs:

Name	PubChem ID	Source	References	Interaction
2ofv	15991573	BindingDB	-	show
3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi	9926791	BindingDB	-	show
4-anilinoquinazoline deriv. 2	4708	BindingDB	-	show
ABT-869	11485656	BindingDB	-	show
AMG 706	11667893	BindingDB	-	show
aminoquinazoline benzamide, 3	16086088	BindingDB	-	show
AST-487	11409972	BindingDB	-	show
Bio2_000413	6610353	BindingDB	-	show
Brivanib	11234052	BindingDB	-	show
Canertinib	156414	BindingDB	-	show
CHEBI:104346	5459219	BindingDB	-	show
CHEBI:259924	44329707	BindingDB	-	show
CHEBI:653046	44419562	BindingDB	-	show
CHEBI:668343	45481533	BindingDB	-	show
CHEBI:668344	45481534	BindingDB	-	show
CHEBI:679372	45486164	BindingDB	-	show
CHEMBL104062	44336174	BindingDB	-	show
CHEMBL104074	9796455	BindingDB	-	show
CHEMBL104409	44335986	BindingDB	-	show
CHEMBL104640	44335927	BindingDB	-	show
CHEMBL104963	44335773	BindingDB	-	show
CHEMBL105255	44335843	BindingDB	-	show
CHEMBL106571	44335857	BindingDB	-	show
CHEMBL106944	44335968	BindingDB	-	show
CHEMBL106961	44335832	BindingDB	-	show
CHEMBL107166	44335938	BindingDB	-	show
CHEMBL107273	44335946	BindingDB	-	show
CHEMBL1076221	46879483	BindingDB	-	show
CHEMBL1076700	46880785	BindingDB	-	show
CHEMBL1077575	25062228	BindingDB	-	show
CHEMBL1077841	46882802	BindingDB	-	show
CHEMBL1077842	25063021	BindingDB	-	show
CHEMBL1078005	25059112	BindingDB	-	show
CHEMBL1078159	25062765	BindingDB	-	show
CHEMBL1078165	25062226	BindingDB	-	show
CHEMBL1078166	25060146	BindingDB	-	show
CHEMBL1078228	25059626	BindingDB	-	show
CHEMBL1078229	25061949	BindingDB	-	show
CHEMBL1078274	25061685	BindingDB	-	show
CHEMBL1078275	46882470	BindingDB	-	show
CHEMBL1078276	46882471	BindingDB	-	show
CHEMBL1078277	46882472	BindingDB	-	show
CHEMBL1078363	25062498	BindingDB	-	show
CHEMBL1078364	25060927	BindingDB	-	show
CHEMBL1078370	25063023	BindingDB	-	show
CHEMBL1078453	25061950	BindingDB	-	show
CHEMBL1078688	46882539	BindingDB	-	show
CHEMBL1078689	46882540	BindingDB	-	show
CHEMBL1078720	25063025	BindingDB	-	show
CHEMBL1078721	25061435	BindingDB	-	show
CHEMBL1078767	46882541	BindingDB	-	show
CHEMBL1078866	46882542	BindingDB	-	show
CHEMBL1078889	46882590	BindingDB	-	show
CHEMBL1078933	46882803	BindingDB	-	show
CHEMBL1078934	25060922	BindingDB	-	show
CHEMBL1078971	46882589	BindingDB	-	show
CHEMBL1079077	46882591	BindingDB	-	show
CHEMBL1079078	46882592	BindingDB	-	show
CHEMBL1079120	25060677	BindingDB	-	show
CHEMBL1079121	25059891	BindingDB	-	show
CHEMBL1079523	46879420	BindingDB	-	show
CHEMBL1079524	46879421	BindingDB	-	show
CHEMBL1079525	46879422	BindingDB	-	show
CHEMBL1079526	46879423	BindingDB	-	show
CHEMBL1079593	45375955	BindingDB	-	show
CHEMBL1079594	45375956	BindingDB	-	show
CHEMBL1080110	46879484	BindingDB	-	show
CHEMBL1080111	46879485	BindingDB	-	show
CHEMBL1080159	46865431	BindingDB	-	show
CHEMBL1080322	46880193	BindingDB	-	show
CHEMBL1080323	46880194	BindingDB	-	show
CHEMBL1080332	46880196	BindingDB	-	show
CHEMBL1080333	46880197	BindingDB	-	show
CHEMBL1081190	11951225	BindingDB	-	show
CHEMBL1081290	24800423	BindingDB	-	show
CHEMBL1081291	24800604	BindingDB	-	show
CHEMBL1081292	24800602	BindingDB	-	show
CHEMBL1081376	46879545	BindingDB	-	show
CHEMBL1081377	11844913	BindingDB	-	show
CHEMBL1081378	46879546	BindingDB	-	show
CHEMBL1081379	45375954	BindingDB	-	show
CHEMBL1081443	24801650	BindingDB	-	show
CHEMBL1081485	46880738	BindingDB	-	show
CHEMBL1081663	46880739	BindingDB	-	show
CHEMBL1081846	46880195	BindingDB	-	show
CHEMBL1081975	24800776	BindingDB	-	show
CHEMBL1081976	46880686	BindingDB	-	show
CHEMBL1081977	24801129	BindingDB	-	show
CHEMBL1081978	46880687	BindingDB	-	show
CHEMBL1082022	46865430	BindingDB	-	show
CHEMBL1082023	46880784	BindingDB	-	show
CHEMBL1085511	24762205	BindingDB	-	show
CHEMBL1087235	46880119	BindingDB	-	show
CHEMBL1087236	46880120	BindingDB	-	show
CHEMBL1088423	46880121	BindingDB	-	show
CHEMBL1088424	46880122	BindingDB	-	show
CHEMBL1088856	25123475	BindingDB	-	show
CHEMBL1088857	25123807	BindingDB	-	show
CHEMBL1089773	46865529	BindingDB	-	show
CHEMBL1089813	46885231	BindingDB	-	show
CHEMBL1089814	46885232	BindingDB	-	show
CHEMBL1089815	46885234	BindingDB	-	show
CHEMBL1089833	25123806	BindingDB	-	show
CHEMBL1091190	46885052	BindingDB	-	show
CHEMBL1091191	46885053	BindingDB	-	show
CHEMBL1091565	25123154	BindingDB	-	show
CHEMBL1092063	46885233	BindingDB	-	show
CHEMBL1092588	25123474	BindingDB	-	show
CHEMBL1092840	46885289	BindingDB	-	show
CHEMBL1092925	46865530	BindingDB	-	show
CHEMBL1092926	46398810	BindingDB	-	show
CHEMBL1093119	46885290	BindingDB	-	show
CHEMBL1093191	25123155	BindingDB	-	show
CHEMBL1093454	25123808	BindingDB	-	show
CHEMBL1093468	25123472	BindingDB	-	show
CHEMBL1093749	25128110	BindingDB	-	show
CHEMBL1221633	46934144	BindingDB	-	show
CHEMBL1240703	52945601	BindingDB	-	show
CHEMBL1242977	46929544	BindingDB	-	show
CHEMBL1243200	46929748	BindingDB	-	show
CHEMBL1243326	46929857	BindingDB	-	show
CHEMBL1258913	11847343	BindingDB	-	show
CHEMBL1270230	24809764	BindingDB	-	show
CHEMBL1287812	52944839	BindingDB	-	show
CHEMBL1287854	50878566	BindingDB	-	show
CHEMBL1287883	52947304	BindingDB	-	show
CHEMBL1287910	52942437	BindingDB	-	show
CHEMBL1287940	52941228	BindingDB	-	show
CHEMBL1287941	52948526	BindingDB	-	show
CHEMBL1287971	20820292	BindingDB	-	show
CHEMBL1288001	52943663	BindingDB	-	show
CHEMBL1288002	52948550	BindingDB	-	show
CHEMBL1288032	52948562	BindingDB	-	show
CHEMBL1288062	52943672	BindingDB	-	show
CHEMBL1290746	49838879	BindingDB	-	show
CHEMBL131577	9927718	BindingDB	-	show
CHEMBL185140	16723801	BindingDB	-	show
CHEMBL201307	9916282	BindingDB	-	show
CHEMBL212128	16086091	BindingDB	-	show
CHEMBL212181	16086078	BindingDB	-	show
CHEMBL212183	16086103	BindingDB	-	show
CHEMBL212195	16086117	BindingDB	-	show
CHEMBL212953	15991575	BindingDB	-	show
CHEMBL213290	16086115	BindingDB	-	show
CHEMBL213478	16086093	BindingDB	-	show
CHEMBL213831	16086107	BindingDB	-	show
CHEMBL214495	16086105	BindingDB	-	show
CHEMBL214530	16086116	BindingDB	-	show
CHEMBL214556	16086118	BindingDB	-	show
CHEMBL215019	16086102	BindingDB	-	show
CHEMBL215691	16086077	BindingDB	-	show
CHEMBL215813	11510392	BindingDB	-	show
CHEMBL215863	16086142	BindingDB	-	show
CHEMBL215943	16086114	BindingDB	-	show
CHEMBL215952	16086113	BindingDB	-	show
CHEMBL215969	16086099	BindingDB	-	show
CHEMBL217937	44419532	BindingDB	-	show
CHEMBL218439	44419475	BindingDB	-	show
CHEMBL218579	44419559	BindingDB	-	show
CHEMBL218602	44419499	BindingDB	-	show
CHEMBL218746	44419498	BindingDB	-	show
CHEMBL220483	44419524	BindingDB	-	show
CHEMBL220484	44419547	BindingDB	-	show
CHEMBL220585	44419523	BindingDB	-	show
CHEMBL220969	44419544	BindingDB	-	show
CHEMBL221029	44419491	BindingDB	-	show
CHEMBL221037	44419485	BindingDB	-	show
CHEMBL221038	44419522	BindingDB	-	show
CHEMBL221376	44419528	BindingDB	-	show
CHEMBL221378	44419556	BindingDB	-	show
CHEMBL221912	16126645	BindingDB	-	show
CHEMBL221976	44419492	BindingDB	-	show
CHEMBL222027	44419493	BindingDB	-	show
CHEMBL222028	44419527	BindingDB	-	show
CHEMBL231733	44432185	BindingDB	-	show
CHEMBL231821	44430898	BindingDB	-	show
CHEMBL231822	44430900	BindingDB	-	show
CHEMBL231925	44432193	BindingDB	-	show
CHEMBL231948	44432187	BindingDB	-	show
CHEMBL231949	44432188	BindingDB	-	show
CHEMBL232033	44430902	BindingDB	-	show
CHEMBL232147	16664854	BindingDB	-	show
CHEMBL232149	44432191	BindingDB	-	show
CHEMBL233151	44432177	BindingDB	-	show
CHEMBL233555	44432180	BindingDB	-	show
CHEMBL233854	44430914	BindingDB	-	show
CHEMBL233856	44430915	BindingDB	-	show
CHEMBL233969	44432183	BindingDB	-	show
CHEMBL234066	16216717	BindingDB	-	show
CHEMBL234086	19917815	BindingDB	-	show
CHEMBL234292	44430889	BindingDB	-	show
CHEMBL234293	25070618	BindingDB	-	show
CHEMBL234718	25070619	BindingDB	-	show
CHEMBL234936	44430894	BindingDB	-	show
CHEMBL234937	44430896	BindingDB	-	show
CHEMBL243015	44430903	BindingDB	-	show
CHEMBL243016	44430905	BindingDB	-	show
CHEMBL243018	44430910	BindingDB	-	show
CHEMBL245172	44430907	BindingDB	-	show
CHEMBL247468	11684933	BindingDB	-	show
CHEMBL247866	11626406	BindingDB	-	show
CHEMBL318390	44335849	BindingDB	-	show
CHEMBL319556	23532567	BindingDB	-	show
CHEMBL320646	44335848	BindingDB	-	show
CHEMBL321855	44335947	BindingDB	-	show
CHEMBL323994	9947841	BindingDB	-	show
CHEMBL364623	11153014	BindingDB	-	show
CHEMBL373523	44419516	BindingDB	-	show
CHEMBL374321	44419533	BindingDB	-	show
CHEMBL374854	44419515	BindingDB	-	show
CHEMBL375076	44419526	BindingDB	-	show
CHEMBL375205	44419548	BindingDB	-	show
CHEMBL375296	44419474	BindingDB	-	show
CHEMBL376885	44419481	BindingDB	-	show
CHEMBL377734	11632737	BindingDB	-	show
CHEMBL384820	44419502	BindingDB	-	show
CHEMBL384942	16086076	BindingDB	-	show
CHEMBL385055	16086108	BindingDB	-	show
CHEMBL385114	44419478	BindingDB	-	show
CHEMBL385598	16086106	BindingDB	-	show
CHEMBL386661	16086104	BindingDB	-	show
CHEMBL388220	44430909	BindingDB	-	show
CHEMBL388221	44430911	BindingDB	-	show
CHEMBL389797	44430904	BindingDB	-	show
CHEMBL391096	44432184	BindingDB	-	show
CHEMBL391492	44432179	BindingDB	-	show
CHEMBL392371	44432192	BindingDB	-	show
CHEMBL392998	44432190	BindingDB	-	show
CHEMBL393375	44432189	BindingDB	-	show
CHEMBL394174	44432182	BindingDB	-	show
CHEMBL396194	25070616	BindingDB	-	show
CHEMBL396213	44430901	BindingDB	-	show
CHEMBL396449	25070617	BindingDB	-	show
CHEMBL397663	44430895	BindingDB	-	show
CHEMBL397664	44430897	BindingDB	-	show
CHEMBL421213	44335985	BindingDB	-	show
CHEMBL424719	16086092	BindingDB	-	show
CHEMBL427226	16086101	BindingDB	-	show
CHEMBL427233	16086100	BindingDB	-	show
CHEMBL457871	25180101	BindingDB	-	show
CHEMBL458333	25154877	BindingDB	-	show
CHEMBL459044	44562721	BindingDB	-	show
CHEMBL459769	20111936	BindingDB	-	show
CHEMBL462168	11398307	BindingDB	-	show
CHEMBL480411	24963047	BindingDB	-	show
CHEMBL493169	44219632	BindingDB	-	show
CHEMBL494221	44219633	BindingDB	-	show
CHEMBL502156	25263033	BindingDB	-	show
CHEMBL550791	45269930	BindingDB	-	show
CHEMBL551140	44188627	BindingDB	-	show
CHEMBL557101	45273358	BindingDB	-	show
CHEMBL557559	45273361	BindingDB	-	show
CHEMBL557709	25069658	BindingDB	-	show
CHEMBL557846	45272482	BindingDB	-	show
CHEMBL558115	45273364	BindingDB	-	show
CHEMBL558241	45272486	BindingDB	-	show
CHEMBL559787	45269074	BindingDB	-	show
CHEMBL562934	25069976	BindingDB	-	show
CHEMBL563588	45273357	BindingDB	-	show
CHEMBL563795	45269072	BindingDB	-	show
CHEMBL564940	45267327	BindingDB	-	show
CHEMBL565066	45271570	BindingDB	-	show
CHEMBL568790	45486163	BindingDB	-	show
CHEMBL568815	44158660	BindingDB	-	show
CHEMBL568816	44159594	BindingDB	-	show
CHEMBL568866	45486119	BindingDB	-	show
CHEMBL569012	44159711	BindingDB	-	show
CHEMBL569091	45486120	BindingDB	-	show
CHEMBL569092	45486121	BindingDB	-	show
CHEMBL569720	45375974	BindingDB	-	show
CHEMBL569721	45486136	BindingDB	-	show
CHEMBL569737	45486106	BindingDB	-	show
CHEMBL569738	25171663	BindingDB	-	show
CHEMBL569739	44160079	BindingDB	-	show
CHEMBL569757	45486113	BindingDB	-	show
CHEMBL569948	45486138	BindingDB	-	show
CHEMBL569957	45486139	BindingDB	-	show
CHEMBL569966	45486142	BindingDB	-	show
CHEMBL570002	25171665	BindingDB	-	show
CHEMBL570192	45486168	BindingDB	-	show
CHEMBL570206	44158549	BindingDB	-	show
CHEMBL570217	44159001	BindingDB	-	show
CHEMBL570229	44158886	BindingDB	-	show
CHEMBL570230	45486157	BindingDB	-	show
CHEMBL570231	45486158	BindingDB	-	show
CHEMBL570456	45486159	BindingDB	-	show
CHEMBL570462	45486130	BindingDB	-	show
CHEMBL570668	45486109	BindingDB	-	show
CHEMBL570686	44159590	BindingDB	-	show
CHEMBL570890	42641406	BindingDB	-	show
CHEMBL570899	25171661	BindingDB	-	show
CHEMBL571118	45486147	BindingDB	-	show
CHEMBL571119	45486148	BindingDB	-	show
CHEMBL571526	45486169	BindingDB	-	show
CHEMBL576068	25172086	BindingDB	-	show
CHEMBL576257	25171666	BindingDB	-	show
CHEMBL576272	45486137	BindingDB	-	show
CHEMBL576286	25171877	BindingDB	-	show
CHEMBL576475	44159959	BindingDB	-	show
CHEMBL576476	44158553	BindingDB	-	show
CHEMBL576486	45486124	BindingDB	-	show
CHEMBL576862	45486170	BindingDB	-	show
CHEMBL577944	45486118	BindingDB	-	show
CHEMBL578194	25171876	BindingDB	-	show
CHEMBL578201	45486156	BindingDB	-	show
CHEMBL582808	44158658	BindingDB	-	show
CHEMBL583030	44159962	BindingDB	-	show
CHEMBL583895	44160207	BindingDB	-	show
CHEMBL584052	44605611	BindingDB	-	show
CHEMBL584322	44159839	BindingDB	-	show
CHEMBL584944	44159000	BindingDB	-	show
CHEMBL585527	45486129	BindingDB	-	show
CHEMBL585927	44622837	BindingDB	-	show
CHEMBL597754	46233287	BindingDB	-	show
CHEMBL599224	45139989	BindingDB	-	show
CHEMBL599428	45139991	BindingDB	-	show
CHEMBL87325	10658651	BindingDB	-	show
CHIR-265	11656518	BindingDB	-	show
CID 11496629	11696609	BindingDB	-	show
CID 9926791	9818231	BindingDB	-	show
CID 9926791	9966538	BindingDB	-	show
CP-724714	9874913	BindingDB	-	show
Dasatinib	3062316	BindingDB	-	show
Doramapimod	156422	BindingDB	-	show
Erlotinib	176870	BindingDB	-	show
Gefitinib	123631	BindingDB	-	show
GW-2580	11617559	BindingDB	-	show
Imatinib Methansulfonate	5291	BindingDB	-	show
Indolinone based inhibitor, 3d	23644715	BindingDB	-	show
JAK Inhibitor I	5494425	BindingDB	-	show
JAK3 Inhibitor I	3794	PROMISCUOUS	PMID 18094329	show
Kinome_2481	46224684	BindingDB	-	show
Kinome_2918	44444843	BindingDB	-	show
Kinome_714	46886323	BindingDB	-	show
L2G	9549184	BindingDB	-	show
Lapatinib ditosylate	208908	BindingDB	-	show
Lestaurtinib	126565	BindingDB	-	show
MASTPROM	3795	PROMISCUOUS	PMID 18094329	show
MLN8054	11712649	BindingDB	-	show
oxindole i	5908088	BindingDB	-	show
Pazopanib	10113978	BindingDB	-	show
PI-103	9884685	BindingDB	-	show
PKC-412	9829523	BindingDB	-	show
Roscovitine	160355	BindingDB	-	show
Ruboxistaurin	153999	BindingDB	-	show
RWJ-387252	5330790	BindingDB	-	show
S1018_Selleck	9977819	BindingDB	-	show
S1147_Selleck	16007391	BindingDB	-	show
S1526_Selleck	24889392	BindingDB	-	show
S2219_Selleck	25062766	BindingDB	-	show
SB 202190	5353940	BindingDB	-	show
SB-431542	4521392	BindingDB	-	show
SNS-032	3025986	BindingDB	-	show
sorafenibum	216239	BindingDB	-	show
STAUROSPORINE	44259	BindingDB	-	show
staurosporine	44299148	BindingDB	-	show
Staurosporine aglycone	3815	BindingDB	-	show
SU-14813	10138259	BindingDB	-	show
Sunitinib	5329102	BindingDB	-	show
Tandutinib	3038522	BindingDB	-	show
Tg-101348	16722836	BindingDB	-	show
Vandetanib	3081361	BindingDB	-	show
Vatalanib	151194	BindingDB	-	show
VX-680	5494449	BindingDB	-	show
VX-745	3038525	BindingDB	-	show

enlarge table

Synonyms:

JAK-3

Janus kinase 3

L-JAK

Leukocyte janus kinase

Tyrosine-protein kinase JAK3

enlarge table

Similar targets:

Uniprot name	% Sequence similarity	% Sequence identity
JAK3_MOUSE	87.8	82.2
JAK3_RAT	86.2	80
JAK2_HUMAN	65.9	48.1
JAK2_RAT	65.7	48
RET_HUMAN	31.6	21.3
IGF1R_HUMAN	31.2	19.5
DDR1_HUMAN	31.1	21.4
P93098_CERPU	30.9	19.3
KPCD1_HUMAN	30.2	18.6
FGFR1_HUMAN	30	19.1
EMBC_MYCTU	29.7	17.9
KPCD1_MOUSE	29.6	18.7
EPHA2_HUMAN	29.5	19.2
HXK2_RAT	29.5	17.8
Q41460_SOLTU	29.4	15.3
PDE3A_HUMAN	29.2	18.1
TETX_CLOTE	29.2	15.9
PUTA_ECOLI	29.1	18.5
FLT3_HUMAN	28.6	18.5
P94692_DESAF	28.6	16.4
TOP2_CRIFA	28.6	16.3
VGFR2_HUMAN	28.4	18.9
RGYR_ARCFU	28.4	16.5
FGFR1_MOUSE	28.3	18.8
EGFR_HUMAN	28.1	17.6
SYI_THET8	28.1	17.8
SYAM_HUMAN	28	18.6
METH_HUMAN	28	16.9
TLR9_HUMAN	28	19.1
CARB_ECOLI	28	15.9

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Protein-Protein Interactions:

Uniprot name	Source
VILI_HUMAN	PMID 17537734
TIAF1_HUMAN	2 PMIDs
SOCS3_HUMAN	3 PMIDs
SOCS1_HUMAN	4 PMIDs
SHB_HUMAN	5 PMIDs
SH2B2_HUMAN	6 PMIDs
LEPR_HUMAN	7 PMIDs
KHDR1_HUMAN	8 PMIDs
JAK3_HUMAN	9 PMIDs
IL7RA_HUMAN	10 PMIDs
IL4RA_HUMAN	11 PMIDs
IL2RG_HUMAN	12 PMIDs
IL2RB_HUMAN	13 PMIDs

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