Target Details

Name:	JAK-2
Uniprot name:	JAK2_HUMAN
Accession Numbers:	O14636 O60674 O75297
EC-Number:	2.7.10.2
Organism:	Homo sapiens Human
PDB IDs:	2B7A 2W1I 3E62 3E63 3E64 3FUP
KEGG Pathways:	show KEGG Pathways
Drugs:	Name PubChem ID Source References Interaction 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi 9926791 BindingDB - show 5-bromo-1H-indazol-3-amine 817910 BindingDB - show 5-phenyl-1H-indazol-3-amine 11492186 BindingDB - show 6-bromo-1H-indazol-3-amine 2786631 BindingDB - show 6-phenyl-1H-indazol-3-amine 11658542 BindingDB - show 7PY 11957393 BindingDB - show ABT-869 11485656 BindingDB - show AC1NV8WC 5473838 BindingDB - show AMG 706 11667893 BindingDB - show AST-487 11409972 BindingDB - show Bio2_000413 6610353 BindingDB - show Canertinib 156414 BindingDB - show CHEBI:104346 5459219 BindingDB - show CHEBI:259924 44329707 BindingDB - show CHEBI:653046 44419562 BindingDB - show CHEBI:668343 45481533 BindingDB - show CHEBI:668344 45481534 BindingDB - show CHEBI:679372 45486164 BindingDB - show CHEMBL104074 9796455 BindingDB - show CHEMBL1076221 46879483 BindingDB - show CHEMBL1076700 46880785 BindingDB - show CHEMBL1076721 22353185 BindingDB - show CHEMBL1077431 46882362 BindingDB - show CHEMBL1077458 24877326 BindingDB - show CHEMBL1077575 25062228 BindingDB - show CHEMBL1077841 46882802 BindingDB - show CHEMBL1077842 25063021 BindingDB - show CHEMBL1078005 25059112 BindingDB - show CHEMBL1078159 25062765 BindingDB - show CHEMBL1078165 25062226 BindingDB - show CHEMBL1078166 25060146 BindingDB - show CHEMBL1078228 25059626 BindingDB - show CHEMBL1078229 25061949 BindingDB - show CHEMBL1078274 25061685 BindingDB - show CHEMBL1078275 46882470 BindingDB - show CHEMBL1078276 46882471 BindingDB - show CHEMBL1078277 46882472 BindingDB - show CHEMBL1078363 25062498 BindingDB - show CHEMBL1078364 25060927 BindingDB - show CHEMBL1078370 25063023 BindingDB - show CHEMBL1078453 25061950 BindingDB - show CHEMBL1078688 46882539 BindingDB - show CHEMBL1078689 46882540 BindingDB - show CHEMBL1078720 25063025 BindingDB - show CHEMBL1078721 25061435 BindingDB - show CHEMBL1078767 46882541 BindingDB - show CHEMBL1078866 46882542 BindingDB - show CHEMBL1078889 46882590 BindingDB - show CHEMBL1078933 46882803 BindingDB - show CHEMBL1078934 25060922 BindingDB - show CHEMBL1078971 46882589 BindingDB - show CHEMBL1078984 25062767 BindingDB - show CHEMBL1079077 46882591 BindingDB - show CHEMBL1079078 46882592 BindingDB - show CHEMBL1079120 25060677 BindingDB - show CHEMBL1079121 25059891 BindingDB - show CHEMBL1079523 46879420 BindingDB - show CHEMBL1079524 46879421 BindingDB - show CHEMBL1079525 46879422 BindingDB - show CHEMBL1079526 46879423 BindingDB - show CHEMBL1079593 45375955 BindingDB - show CHEMBL1079594 45375956 BindingDB - show CHEMBL1079689 46882360 BindingDB - show CHEMBL1079690 46882361 BindingDB - show CHEMBL1080110 46879484 BindingDB - show CHEMBL1080111 46879485 BindingDB - show CHEMBL1080159 46865431 BindingDB - show CHEMBL1080322 46880193 BindingDB - show CHEMBL1080323 46880194 BindingDB - show CHEMBL1080332 46880196 BindingDB - show CHEMBL1080333 46880197 BindingDB - show CHEMBL1080394 46882359 BindingDB - show CHEMBL1080395 25061438 BindingDB - show CHEMBL1080411 46882412 BindingDB - show CHEMBL1080902 46865325 BindingDB - show CHEMBL1080954 46882409 BindingDB - show CHEMBL1080955 46882410 BindingDB - show CHEMBL1081138 46882411 BindingDB - show CHEMBL1081190 11951225 BindingDB - show CHEMBL1081290 24800423 BindingDB - show CHEMBL1081291 24800604 BindingDB - show CHEMBL1081292 24800602 BindingDB - show CHEMBL1081376 46879545 BindingDB - show CHEMBL1081377 11844913 BindingDB - show CHEMBL1081378 46879546 BindingDB - show CHEMBL1081379 45375954 BindingDB - show CHEMBL1081443 24801650 BindingDB - show CHEMBL1081485 46880738 BindingDB - show CHEMBL1081663 46880739 BindingDB - show CHEMBL1081664 46865657 BindingDB - show CHEMBL1081846 46880195 BindingDB - show CHEMBL1081975 24800776 BindingDB - show CHEMBL1081976 46880686 BindingDB - show CHEMBL1081977 24801129 BindingDB - show CHEMBL1081978 46880687 BindingDB - show CHEMBL1082022 46865430 BindingDB - show CHEMBL1082023 46880784 BindingDB - show CHEMBL1085511 24762205 BindingDB - show CHEMBL1086736 46880951 BindingDB - show CHEMBL1087235 46880119 BindingDB - show CHEMBL1087236 46880120 BindingDB - show CHEMBL1087269 25102935 BindingDB - show CHEMBL1087898 25171662 BindingDB - show CHEMBL1088030 25104741 BindingDB - show CHEMBL1088423 46880121 BindingDB - show CHEMBL1088424 46880122 BindingDB - show CHEMBL1088856 25123475 BindingDB - show CHEMBL1088857 25123807 BindingDB - show CHEMBL1089773 46865529 BindingDB - show CHEMBL1089813 46885231 BindingDB - show CHEMBL1089814 46885232 BindingDB - show CHEMBL1089815 46885234 BindingDB - show CHEMBL1089833 25123806 BindingDB - show CHEMBL1091190 46885052 BindingDB - show CHEMBL1091191 46885053 BindingDB - show CHEMBL1091565 25123154 BindingDB - show CHEMBL1092063 46885233 BindingDB - show CHEMBL1092588 25123474 BindingDB - show CHEMBL1092840 46885289 BindingDB - show CHEMBL1092925 46865530 BindingDB - show CHEMBL1092926 46398810 BindingDB - show CHEMBL1093119 46885290 BindingDB - show CHEMBL1093191 25123155 BindingDB - show CHEMBL1093454 25123808 BindingDB - show CHEMBL1093468 25123472 BindingDB - show CHEMBL1093749 25128110 BindingDB - show CHEMBL1221633 46934144 BindingDB - show CHEMBL1240703 52945601 BindingDB - show CHEMBL1242977 46929544 BindingDB - show CHEMBL1243200 46929748 BindingDB - show CHEMBL1243326 46929857 BindingDB - show CHEMBL1258913 11847343 BindingDB - show CHEMBL1270230 24809764 BindingDB - show CHEMBL1270399 46868971 BindingDB - show CHEMBL1287812 52944839 BindingDB - show CHEMBL1287854 50878566 BindingDB - show CHEMBL1287883 52947304 BindingDB - show CHEMBL1287910 52942437 BindingDB - show CHEMBL1287940 52941228 BindingDB - show CHEMBL1287941 52948526 BindingDB - show CHEMBL1288001 52943663 BindingDB - show CHEMBL1288002 52948550 BindingDB - show CHEMBL1288032 52948562 BindingDB - show CHEMBL1288062 52943672 BindingDB - show CHEMBL1288720 52944434 BindingDB - show CHEMBL1289095 25096020 BindingDB - show CHEMBL1289096 25096279 BindingDB - show CHEMBL1289097 50925513 BindingDB - show CHEMBL1289216 52942701 BindingDB - show CHEMBL1289217 52942702 BindingDB - show CHEMBL1289218 25096016 BindingDB - show CHEMBL1289991 52941200 BindingDB - show CHEMBL1289992 52948490 BindingDB - show CHEMBL1290089 52949754 BindingDB - show CHEMBL1290090 52942449 BindingDB - show CHEMBL1290196 52949761 BindingDB - show CHEMBL1290197 52947324 BindingDB - show CHEMBL1290308 52941284 BindingDB - show CHEMBL1290309 52949798 BindingDB - show CHEMBL1290310 52946111 BindingDB - show CHEMBL1290423 52947390 BindingDB - show CHEMBL1290424 25096277 BindingDB - show CHEMBL1290533 25096276 BindingDB - show CHEMBL1290534 25097027 BindingDB - show CHEMBL1290650 25096532 BindingDB - show CHEMBL1290651 52948678 BindingDB - show CHEMBL1290767 52946313 BindingDB - show CHEMBL1290768 52947547 BindingDB - show CHEMBL1290769 25096019 BindingDB - show CHEMBL185140 16723801 BindingDB - show CHEMBL217937 44419532 BindingDB - show CHEMBL218439 44419475 BindingDB - show CHEMBL218579 44419559 BindingDB - show CHEMBL218602 44419499 BindingDB - show CHEMBL218746 44419498 BindingDB - show CHEMBL220483 44419524 BindingDB - show CHEMBL220484 44419547 BindingDB - show CHEMBL220585 44419523 BindingDB - show CHEMBL220969 44419544 BindingDB - show CHEMBL221029 44419491 BindingDB - show CHEMBL221037 44419485 BindingDB - show CHEMBL221038 44419522 BindingDB - show CHEMBL221376 44419528 BindingDB - show CHEMBL221378 44419556 BindingDB - show CHEMBL221912 16126645 BindingDB - show CHEMBL221976 44419492 BindingDB - show CHEMBL222027 44419493 BindingDB - show CHEMBL222028 44419527 BindingDB - show CHEMBL231733 44432185 BindingDB - show CHEMBL231925 44432193 BindingDB - show CHEMBL231948 44432187 BindingDB - show CHEMBL231949 44432188 BindingDB - show CHEMBL232147 16664854 BindingDB - show CHEMBL232149 44432191 BindingDB - show CHEMBL233151 44432177 BindingDB - show CHEMBL233555 44432180 BindingDB - show CHEMBL233969 44432183 BindingDB - show CHEMBL246356 17748275 BindingDB - show CHEMBL247468 11684933 BindingDB - show CHEMBL247866 11626406 BindingDB - show CHEMBL253292 24882503 BindingDB - show CHEMBL319556 23532567 BindingDB - show CHEMBL323994 9947841 BindingDB - show CHEMBL373523 44419516 BindingDB - show CHEMBL374321 44419533 BindingDB - show CHEMBL374854 44419515 BindingDB - show CHEMBL375076 44419526 BindingDB - show CHEMBL375205 44419548 BindingDB - show CHEMBL375296 44419474 BindingDB - show CHEMBL376885 44419481 BindingDB - show CHEMBL384820 44419502 BindingDB - show CHEMBL385114 44419478 BindingDB - show CHEMBL391096 44432184 BindingDB - show CHEMBL391492 44432179 BindingDB - show CHEMBL392371 44432192 BindingDB - show CHEMBL392998 44432190 BindingDB - show CHEMBL393375 44432189 BindingDB - show CHEMBL394174 44432182 BindingDB - show CHEMBL447670 44570436 BindingDB - show CHEMBL455428 11675054 BindingDB - show CHEMBL457871 25180101 BindingDB - show CHEMBL459769 20111936 BindingDB - show CHEMBL462168 11398307 BindingDB - show CHEMBL475817 11626920 BindingDB - show CHEMBL479619 44570386 BindingDB - show CHEMBL479620 44570387 BindingDB - show CHEMBL479830 44570474 BindingDB - show CHEMBL480411 24963047 BindingDB - show CHEMBL480412 44570437 BindingDB - show CHEMBL480606 44570438 BindingDB - show CHEMBL480998 44570435 BindingDB - show CHEMBL481583 44570391 BindingDB - show CHEMBL481584 44570388 BindingDB - show CHEMBL481585 44570392 BindingDB - show CHEMBL481985 11601868 BindingDB - show CHEMBL482187 44570476 BindingDB - show CHEMBL482188 44570477 BindingDB - show CHEMBL482189 25181422 BindingDB - show CHEMBL493169 44219632 BindingDB - show CHEMBL494221 44219633 BindingDB - show CHEMBL498859 44570390 BindingDB - show CHEMBL510641 44570389 BindingDB - show CHEMBL519279 44570434 BindingDB - show CHEMBL520947 44570475 BindingDB - show CHEMBL551570 45272300 BindingDB - show CHEMBL560245 45267171 BindingDB - show CHEMBL563080 45273165 BindingDB - show CHEMBL563257 45273175 BindingDB - show CHEMBL563555 45272290 BindingDB - show CHEMBL564365 45267176 BindingDB - show CHEMBL568790 45486163 BindingDB - show CHEMBL568815 44158660 BindingDB - show CHEMBL568816 44159594 BindingDB - show CHEMBL568866 45486119 BindingDB - show CHEMBL569012 44159711 BindingDB - show CHEMBL569091 45486120 BindingDB - show CHEMBL569092 45486121 BindingDB - show CHEMBL569720 45375974 BindingDB - show CHEMBL569721 45486136 BindingDB - show CHEMBL569737 45486106 BindingDB - show CHEMBL569738 25171663 BindingDB - show CHEMBL569739 44160079 BindingDB - show CHEMBL569757 45486113 BindingDB - show CHEMBL569948 45486138 BindingDB - show CHEMBL569957 45486139 BindingDB - show CHEMBL569966 45486142 BindingDB - show CHEMBL570002 25171665 BindingDB - show CHEMBL570192 45486168 BindingDB - show CHEMBL570206 44158549 BindingDB - show CHEMBL570217 44159001 BindingDB - show CHEMBL570229 44158886 BindingDB - show CHEMBL570230 45486157 BindingDB - show CHEMBL570231 45486158 BindingDB - show CHEMBL570456 45486159 BindingDB - show CHEMBL570462 45486130 BindingDB - show CHEMBL570464 25171664 BindingDB - show CHEMBL570668 45486109 BindingDB - show CHEMBL570686 44159590 BindingDB - show CHEMBL570890 42641406 BindingDB - show CHEMBL570899 25171661 BindingDB - show CHEMBL571118 45486147 BindingDB - show CHEMBL571119 45486148 BindingDB - show CHEMBL571526 45486169 BindingDB - show CHEMBL576068 25172086 BindingDB - show CHEMBL576257 25171666 BindingDB - show CHEMBL576272 45486137 BindingDB - show CHEMBL576286 25171877 BindingDB - show CHEMBL576475 44159959 BindingDB - show CHEMBL576476 44158553 BindingDB - show CHEMBL576486 45486124 BindingDB - show CHEMBL576862 45486170 BindingDB - show CHEMBL577944 45486118 BindingDB - show CHEMBL578194 25171876 BindingDB - show CHEMBL578201 45486156 BindingDB - show CHEMBL578974 45483929 BindingDB - show CHEMBL582808 44158658 BindingDB - show CHEMBL583030 44159962 BindingDB - show CHEMBL583105 45483928 BindingDB - show CHEMBL583895 44160207 BindingDB - show CHEMBL584052 44605611 BindingDB - show CHEMBL584322 44159839 BindingDB - show CHEMBL584944 44159000 BindingDB - show CHEMBL585527 45486129 BindingDB - show CHEMBL585927 44622837 BindingDB - show CHEMBL589145 46224911 BindingDB - show CHEMBL589146 46224939 BindingDB - show CHEMBL589385 46224940 BindingDB - show CHEMBL589387 46224971 BindingDB - show CHEMBL589632 44605608 BindingDB - show CHEMBL589633 46224997 BindingDB - show CHEMBL589634 46224998 BindingDB - show CHEMBL589869 46224936 BindingDB - show CHEMBL590854 25132023 BindingDB - show CHEMBL591095 25132384 BindingDB - show CHEMBL591096 46224796 BindingDB - show CHEMBL591800 25130693 BindingDB - show CHEMBL592033 25129655 BindingDB - show CHEMBL592034 46224837 BindingDB - show CHEMBL592035 25129311 BindingDB - show CHEMBL592269 25128955 BindingDB - show CHEMBL592270 25130695 BindingDB - show CHEMBL592520 25132389 BindingDB - show CHEMBL594686 25130691 BindingDB - show CHEMBL594687 46225316 BindingDB - show CHEMBL595305 25132390 BindingDB - show CHEMBL595396 46225269 BindingDB - show CHEMBL595397 46225270 BindingDB - show CHEMBL595626 46225315 BindingDB - show CHEMBL599911 46224835 BindingDB - show CHEMBL599912 25128956 BindingDB - show CHEMBL600562 25131681 BindingDB - show CHEMBL600874 25132021 BindingDB - show CHEMBL600875 25128951 BindingDB - show CHEMBL601268 46224970 BindingDB - show CHEMBL601303 25131017 BindingDB - show CHEMBL601718 25131018 BindingDB - show CHEMBL601925 25132729 BindingDB - show CHEMBL602100 46224972 BindingDB - show CHEMBL602183 46224797 BindingDB - show CHEMBL602648 25132733 BindingDB - show CHEMBL602788 25131021 BindingDB - show CHEMBL602842 46224910 BindingDB - show CHEMBL603048 46224937 BindingDB - show CHEMBL603432 25132387 BindingDB - show CHEMBL603482 46228648 BindingDB - show CHEMBL604037 46224912 BindingDB - show CHEMBL604038 46224913 BindingDB - show CHEMBL604245 46224836 BindingDB - show CHEMBL604246 46224876 BindingDB - show CHEMBL604274 25132388 BindingDB - show CHEMBL604481 25132730 BindingDB - show CHEMBL604578 46224938 BindingDB - show CHEMBL604695 25132025 BindingDB - show CHEMBL604712 10429593 BindingDB - show CHEMBL606355 25133399 BindingDB - show CHEMBL608999 25130358 BindingDB - show CHIR-265 11656518 BindingDB - show CID 11496629 11696609 BindingDB - show CID 9926791 9818231 BindingDB - show CID 9926791 9966538 BindingDB - show CP-724714 9874913 BindingDB - show Dasatinib 3062316 BindingDB - show Doramapimod 156422 BindingDB - show Erlotinib 176870 BindingDB - show Gefitinib 123631 BindingDB - show GW-2580 11617559 BindingDB - show IKK-2 Inhibitor IV 9903786 BindingDB - show Imatinib Methansulfonate 5291 BindingDB - show JAK Inhibitor I 5494425 BindingDB - show JAK Inhibitor I 5494425 DrugBank - show JAK3 Inhibitor I 3794 BindingDB - show Kinome_2481 46224684 BindingDB - show Kinome_2918 44444843 BindingDB - show Kinome_714 46886323 BindingDB - show Lapatinib ditosylate 208908 BindingDB - show Lestaurtinib 126565 BindingDB - show MASTPROM 3795 BindingDB - show MLN8054 11712649 BindingDB - show nchembio.117-comp9 1400 BindingDB - show NVP-TAE684 16038120 BindingDB - show Pazopanib 10113978 BindingDB - show Pelitinib 6445562 BindingDB - show PI-103 9884685 BindingDB - show PKC-412 9829523 BindingDB - show Roscovitine 160355 BindingDB - show Ruboxistaurin 153999 BindingDB - show RWJ-387252 5330790 BindingDB - show S1018_Selleck 9977819 BindingDB - show S1147_Selleck 16007391 BindingDB - show S1526_Selleck 24889392 BindingDB - show S2219_Selleck 25062766 BindingDB - show SB 202190 5353940 BindingDB - show SB-431542 4521392 BindingDB - show SNS-032 3025986 BindingDB - show sorafenibum 216239 BindingDB - show STAUROSPORINE 44259 BindingDB - show staurosporine 44299148 BindingDB - show SU-14813 10138259 BindingDB - show Sunitinib 5329102 BindingDB - show Tandutinib 3038522 BindingDB - show Tg-101348 16722836 BindingDB - show Tyrphostin B42 5328779 BindingDB - show Vandetanib 3081361 BindingDB - show Vatalanib 151194 BindingDB - show VX-680 5494449 BindingDB - show VX-745 3038525 BindingDB - show enlarge table
Synonyms:	JAK-2 Janus kinase 2 Tyrosine-protein kinase JAK2 enlarge table
Similar targets:	Uniprot name % Sequence similarity % Sequence identity JAK2_RAT 97.3 94.6 JAK3_HUMAN 65.9 48.1 JAK3_MOUSE 64 47 JAK3_RAT 63.3 47.1 P93098_CERPU 33.7 19.5 KINH_NEUCR 31.3 17.6 PK3CD_MOUSE 30.9 18.3 IGF1R_HUMAN 30.8 17.5 PK3CD_HUMAN 30.5 18.5 SYI1_STAAU 30.4 15 EPHA2_HUMAN 30.3 18.4 VGFR1_HUMAN 30.1 18 PLD1_HUMAN 29.9 16.2 MET_HUMAN 29.9 18.5 RAD50_PYRFU 29.8 18.2 TETX_CLOTE 29.8 17.5 SYIM_HUMAN 29.5 16.7 SYI_THET8 29.5 17 PK3CB_HUMAN 29.1 16.6 PK3CB_MOUSE 28.8 16.4 SYI_ECOLI 28.7 15.8 DPOD_CANAL 28.6 16 MYOE_DICDI 28.4 16 ODO1_HUMAN 28.3 15.9 HXK1_HUMAN 28.3 16 AASS_HUMAN 28 16.3 FLT3_HUMAN 28 17.2 NTRK1_HUMAN 28 17.9 AMD_HUMAN 28 15.6 TRI_THEAC 28 16.9 enlarge table
Protein-Protein Interactions:	Uniprot name Source UBS3B_HUMAN PMID 12370296 TUB_HUMAN 2 PMIDs TPOR_HUMAN 3 PMIDs TERA_HUMAN 4 PMIDs STAT2_HUMAN 5 PMIDs STAP2_HUMAN 6 PMIDs SOCS3_HUMAN 7 PMIDs SOCS1_HUMAN 8 PMIDs SH2B2_HUMAN 9 PMIDs SH2B1_HUMAN 10 PMIDs PRLR_HUMAN 11 PMIDs PKD1_HUMAN 12 PMIDs OSMR_HUMAN 13 PMIDs MK_HUMAN 14 PMIDs LEPR_HUMAN 15 PMIDs LEPR_HUMAN 16 PMIDs JAK3_HUMAN 17 PMIDs JAK3_HUMAN 18 PMIDs JAK2_HUMAN 19 PMIDs INGR2_HUMAN 20 PMIDs INGR1_HUMAN 21 PMIDs IL6RB_HUMAN 22 PMIDs IL5RA_HUMAN 23 PMIDs IL4RA_HUMAN 24 PMIDs IL3RB_HUMAN 25 PMIDs IL3RA_HUMAN 26 PMIDs IL2RB_HUMAN 27 PMIDs IL23R_HUMAN 28 PMIDs IGF1R_HUMAN 29 PMIDs I12R2_HUMAN 30 PMIDs HES5_HUMAN 31 PMIDs HES1_HUMAN 32 PMIDs GTF2I_HUMAN 33 PMIDs GHR_HUMAN 34 PMIDs G3BP1_HUMAN 35 PMIDs ERBB3_HUMAN 36 PMIDs EPOR_HUMAN 37 PMIDs ELP2_HUMAN 38 PMIDs DNJA3_HUMAN 39 PMIDs CSF3R_HUMAN 40 PMIDs CRLF2_HUMAN 41 PMIDs enlarge table

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