Target Details

Name:	Fibroblast growth factor receptor 2
Uniprot name:	FGFR2_HUMAN
Accession Numbers:	P18443 P21802 Q01742 Q12922 Q14300 Q14301 Q14302 Q14303 Q14304 Q14305 Q14672 Q14718 Q14719 Q1KHY5 Q86YI4 Q96KL9 Q96KM0 Q96KM1 Q96KM2 Q9NZU2 Q9NZU3 Q9UD01 Q9UD02 Q9UIH3 Q9UIH4 Q9UIH5 Q9UIH6 Q9UIH7 Q9UIH8 Q9UM87 Q9UMC6 Q9UNS7 Q9UQH7 Q9UQH8 Q9UQH9 Q9UQI0
EC-Number:	2.7.10.1
Organism:	Homo sapiens Human
PDB IDs:	1DJS 1E0O 1EV2 1GJO 1II4 1IIL 1NUN 1OEC 1WVZ 2FDB 2PSQ 2PVF 2PVY 2PWL 2PY3 2PZ5 2PZP 2PZR 2Q0B 3B2T 3CAF 3CLY 3CU1 3DAR 3EUU
KEGG Pathways:	show KEGG Pathways
Drugs:	Name PubChem ID Source References Interaction 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3c 5330800 BindingDB - show 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3f 5330804 BindingDB - show 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperi 9926791 BindingDB - show 3-[4-(1-FORMYLPIPERAZIN-4-YL)-BENZYLIDENYL]-2-INDOLINONE 1633 DrugBank - show 4-ARYL-2-PHENYLAMINO PYRIMIDINE 447622 DrugBank - show ABT-869 11485656 BindingDB - show AMG 706 11667893 BindingDB - show AST-487 11409972 BindingDB - show Bio2_000413 6610353 BindingDB - show Canertinib 156414 BindingDB - show CHEBI:104346 5459219 BindingDB - show CHEBI:259924 44329707 BindingDB - show CHEBI:668343 45481533 BindingDB - show CHEBI:668344 45481534 BindingDB - show CHEMBL1172957 46898022 BindingDB - show CHEMBL1240703 52945601 BindingDB - show CHEMBL167425 23022716 BindingDB - show CHEMBL168335 44382047 BindingDB - show CHEMBL169397 44382048 BindingDB - show CHEMBL169837 23022671 BindingDB - show CHEMBL169854 23022836 BindingDB - show CHEMBL170415 44382259 BindingDB - show CHEMBL170519 23022708 BindingDB - show CHEMBL170907 23022732 BindingDB - show CHEMBL171161 44382373 BindingDB - show CHEMBL171413 9932979 BindingDB - show CHEMBL171509 44382615 BindingDB - show CHEMBL172746 44382310 BindingDB - show CHEMBL191336 9863538 BindingDB - show CHEMBL215803 16046126 BindingDB - show CHEMBL230686 11562302 BindingDB - show CHEMBL276125 23022691 BindingDB - show CHEMBL352308 9850161 BindingDB - show CHEMBL352342 23022656 BindingDB - show CHEMBL352534 10113795 BindingDB - show CHEMBL353668 44382361 BindingDB - show CHEMBL353884 44382807 BindingDB - show CHEMBL353991 44382037 BindingDB - show CHEMBL354224 44382744 BindingDB - show CHEMBL354830 23022619 BindingDB - show CHEMBL354898 44382790 BindingDB - show CHEMBL354902 44382806 BindingDB - show CHEMBL355436 44382411 BindingDB - show CHEMBL414643 44382531 BindingDB - show CHEMBL569880 24883334 BindingDB - show CHEMBL571040 24883287 BindingDB - show CHEMBL600795 46232443 BindingDB - show CHEMBL602471 46232555 BindingDB - show CHEMBL602472 46232556 BindingDB - show CHIR-265 11656518 BindingDB - show CP-724714 9874913 BindingDB - show Dasatinib 3062316 BindingDB - show Doramapimod 156422 BindingDB - show Erlotinib 176870 BindingDB - show Gefitinib 123631 BindingDB - show GW-2580 11617559 BindingDB - show Imatinib Methansulfonate 5291 BindingDB - show Intedanib 9809715 BindingDB - show JAK Inhibitor I 5494425 BindingDB - show Lapatinib ditosylate 208908 BindingDB - show Lestaurtinib 126565 BindingDB - show MLN8054 11712649 BindingDB - show Pazopanib 10113978 BindingDB - show PI-103 9884685 BindingDB - show PKC-412 9829523 BindingDB - show Pyrazine-Pyridine Biheteroaryl 39 5330388 BindingDB - show Pyrazine-Pyridine Biheteroaryl 41 5330389 BindingDB - show Pyrazine-Pyridine Biheteroaryl 56 5330390 BindingDB - show Pyrazine-Pyridine Biheteroaryl 57 5330391 BindingDB - show Pyrazine-Pyridine Biheteroaryl 58 5330392 BindingDB - show Pyrazine-Pyridine Biheteroaryl 7 5330387 BindingDB - show Roscovitine 160355 BindingDB - show Ruboxistaurin 153999 BindingDB - show RWJ-387252 5330790 BindingDB - show S1018_Selleck 9977819 BindingDB - show S1147_Selleck 16007391 BindingDB - show S1194_Selleck 24756910 BindingDB - show S1363_Selleck 11317348 BindingDB - show S1526_Selleck 24889392 BindingDB - show SB 202190 5353940 BindingDB - show SB-431542 4521392 BindingDB - show SNS-032 3025986 BindingDB - show sorafenibum 216239 BindingDB - show STAUROSPORINE 44259 BindingDB - show staurosporine 44299148 BindingDB - show SU-14813 10138259 BindingDB - show Sunitinib 5329102 BindingDB - show Tandutinib 3038522 BindingDB - show Vandetanib 3081361 BindingDB - show Vatalanib 151194 BindingDB - show VX-680 5494449 BindingDB - show VX-745 3038525 BindingDB - show enlarge table
Synonyms:	CD332 FGFR-2 Fibroblast growth factor receptor 2 Keratinocyte growth factor receptor 2 enlarge table
Similar targets:	Uniprot name % Sequence similarity % Sequence identity FGFR1_MOUSE 82.4 71.1 FGFR1_HUMAN 82.4 71.5 Q99052_MOUSE 76.1 66.1 FGFR3_HUMAN 76 65.8 FGFR4_HUMAN 71.1 57.1 KIT_HUMAN 39.4 25.2 Q6IQ28_HUMAN 39.3 25.1 TYRO3_HUMAN 38.2 24.7 NTRK1_HUMAN 37.9 23.4 CSF1R_HUMAN 35.4 22.3 Q59F04_HUMAN 34.1 23 PGFRB_HUMAN 34.1 22.8 ZAP70_HUMAN 33.9 22 RET_HUMAN 33.8 23.4 FLT3_HUMAN 33.3 22.4 PGFRA_HUMAN 32.8 22.7 KSYK_HUMAN 32.7 20.9 KPCD1_MOUSE 32 17.7 LCK_HUMAN 31.6 20.9 BTK_HUMAN 31.6 19.3 KPCD_MOUSE 31.2 19.8 DDR1_HUMAN 30.9 19.8 PDXD1_HUMAN 30.9 17.1 KPCT_HUMAN 30.8 17.2 BRAF_HUMAN 30.4 18.8 HCK_HUMAN 30.2 19.1 KPC3_DROME 30.2 17.7 MMP9_HUMAN 30 17.3 RELA_STREQ 29.9 18 HEX_ADE02 29.9 16.9 enlarge table
Protein-Protein Interactions:	Uniprot name Source ITA5_HUMAN PMID 15728256 FRS3_HUMAN 2 PMIDs FGFR2_HUMAN 3 PMIDs FGF9_HUMAN 4 PMIDs FGF8_HUMAN 5 PMIDs FGF7_HUMAN 6 PMIDs FGF6_HUMAN 7 PMIDs FGF5_HUMAN 8 PMIDs FGF4_HUMAN 9 PMIDs FGF3_HUMAN 10 PMIDs FGF2_HUMAN 11 PMIDs FGF22_HUMAN 12 PMIDs FGF20_HUMAN 13 PMIDs FGF1_HUMAN 14 PMIDs FGF18_HUMAN 15 PMIDs FGF17_HUMAN 16 PMIDs FGF10_HUMAN 17 PMIDs FAK2_HUMAN 18 PMIDs EPHA4_HUMAN 19 PMIDs CBL_HUMAN 20 PMIDs enlarge table

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