Target Details

Name:	Coagulation factor XI
Uniprot name:	FA11_HUMAN
Accession Numbers:	P03951 Q4W5C2 Q9Y495
EC-Number:	3.4.21.27
Organism:	Homo sapiens Human
PDB IDs:	1XX9 1XXD 1XXF 1ZHM 1ZHP 1ZHR 1ZJD 1ZLR 1ZMJ 1ZML 1ZMN 1ZOM 1ZPB 1ZPC 1ZPZ 1ZRK 1ZSJ 1ZSK 1ZSL 1ZTJ 1ZTK 1ZTL 2F83 2FDA 2J8J 2J8L 3BG8
KEGG Pathways:	show KEGG Pathways
Drugs:	Name PubChem ID Source References Interaction 4-[[1-methyl-5-[(2-methylbenzimidazol-1-yl)methyl]benzimidazol-2-yl]methylamino]benzenecarboximidamide 445756 BindingDB - show AC1OAH34 6857700 BindingDB - show alpha-ketothiazole analogue 10 16098890 BindingDB - show alpha-ketothiazole analogue 11 16098891 BindingDB - show alpha-ketothiazole analogue 12 16098892 BindingDB - show alpha-ketothiazole analogue 13 23646328 BindingDB - show alpha-ketothiazole analogue 14 16098894 BindingDB - show alpha-ketothiazole analogue 15 11273795 BindingDB - show alpha-ketothiazole analogue 16 23646329 BindingDB - show alpha-ketothiazole analogue 17 16098895 BindingDB - show alpha-ketothiazole analogue 18 16098896 BindingDB - show alpha-ketothiazole analogue 19 16098897 BindingDB - show alpha-ketothiazole analogue 20 16098898 BindingDB - show alpha-ketothiazole analogue 21 16098899 BindingDB - show alpha-ketothiazole analogue 22 16098900 BindingDB - show alpha-ketothiazole analogue 23 16098901 BindingDB - show alpha-ketothiazole analogue 24 16098902 BindingDB - show alpha-ketothiazole analogue 25 16098903 BindingDB - show alpha-ketothiazole analogue 26 16098904 BindingDB - show alpha-ketothiazole analogue 27 16098905 BindingDB - show alpha-ketothiazole analogue 28 16098906 BindingDB - show alpha-ketothiazole analogue 29 16098907 BindingDB - show alpha-ketothiazole analogue 30 16098908 BindingDB - show alpha-ketothiazole analogue 31 16098909 BindingDB - show alpha-ketothiazole analogue 32 16098910 BindingDB - show alpha-ketothiazole analogue 33 16098911 BindingDB - show alpha-ketothiazole analogue 34 16098912 BindingDB - show alpha-ketothiazole analogue 35 16098913 BindingDB - show alpha-ketothiazole analogue 36 16098914 BindingDB - show alpha-ketothiazole analogue 7 16098887 BindingDB - show alpha-ketothiazole analogue 8 16098888 BindingDB - show alpha-ketothiazole analogue 9 16098889 BindingDB - show BIBM1015 9953722 BindingDB - show BIBT0871 9600423 BindingDB - show CHEBI:261946 44330487 BindingDB - show CHEBI:646270 44330604 BindingDB - show CHEBI:646303 44330461 BindingDB - show CHEBI:646305 44330619 BindingDB - show CHEBI:649480 18767498 BindingDB - show CHEBI:651462 44461102 BindingDB - show CHEMBL1172449 49798729 BindingDB - show CHEMBL1221852 49864459 BindingDB - show CHEMBL1221913 24849206 BindingDB - show CHEMBL1221915 11271947 BindingDB - show CHEMBL1221916 49864483 BindingDB - show CHEMBL1288925 52942903 BindingDB - show CHEMBL1288926 52948297 BindingDB - show CHEMBL1289860 52941173 BindingDB - show CHEMBL1289978 52943592 BindingDB - show CHEMBL1290074 50908869 BindingDB - show CHEMBL206736 44411666 BindingDB - show CHEMBL207052 44411677 BindingDB - show CHEMBL207143 44411551 BindingDB - show CHEMBL207349 44411777 BindingDB - show CHEMBL207372 44411779 BindingDB - show CHEMBL207453 44411553 BindingDB - show CHEMBL207951 44411585 BindingDB - show CHEMBL208289 44411590 BindingDB - show CHEMBL208405 44411549 BindingDB - show CHEMBL208597 44411817 BindingDB - show CHEMBL208645 44411808 BindingDB - show CHEMBL210434 44411687 BindingDB - show CHEMBL210624 44411818 BindingDB - show CHEMBL210637 44411636 BindingDB - show CHEMBL210731 44411800 BindingDB - show CHEMBL211921 44416570 BindingDB - show CHEMBL213434 44416548 BindingDB - show CHEMBL215135 44416656 BindingDB - show CHEMBL215750 44416546 BindingDB - show CHEMBL233992 9954980 BindingDB - show CHEMBL237705 44434815 BindingDB - show CHEMBL255407 44453326 BindingDB - show CHEMBL257315 44453328 BindingDB - show CHEMBL271508 44453367 BindingDB - show CHEMBL378011 44411821 BindingDB - show CHEMBL380455 44411556 BindingDB - show CHEMBL382229 44411550 BindingDB - show CHEMBL383007 44411560 BindingDB - show CHEMBL383645 11408882 BindingDB - show CHEMBL384180 44416510 BindingDB - show CHEMBL392297 44434835 BindingDB - show CHEMBL394129 44434818 BindingDB - show CHEMBL398380 11237163 BindingDB - show CHEMBL399593 11351302 BindingDB - show CHEMBL401235 44434809 BindingDB - show CHEMBL403042 10275412 BindingDB - show CHEMBL403113 11341176 BindingDB - show CHEMBL425786 44416572 BindingDB - show CHEMBL437555 24180463 BindingDB - show CHEMBL450578 44432538 BindingDB - show CHEMBL505986 44587263 BindingDB - show CHEMBL506240 44587264 BindingDB - show CHEMBL506501 44587290 BindingDB - show CHEMBL506502 44587291 BindingDB - show CHEMBL506769 44587292 BindingDB - show CHEMBL527117 44587314 BindingDB - show CID 9918215 11399867 BindingDB - show CLAVATADINE A 24881875 BindingDB - show CLAVATADINE B 24881874 BindingDB - show gamma-Glutamylcysteinylglycine 124886 SuperTarget - show Grassystatin A 44255320 BindingDB - show Razaxaban 204102 BindingDB - show enlarge table
Synonyms:	Coagulation factor XI FXI Plasma thromboplastin antecedent PTA enlarge table
Similar targets:	Uniprot name % Sequence similarity % Sequence identity THRB_MOUSE 35.8 24.2 THRB_HUMAN 34.9 23.6 THRB_BOVIN 34.7 24.3 B8ZX62_HUMAN 34.2 23.4 TPA_HUMAN 34 23.2 FA10_HUMAN 33.6 20.9 MASP2_RAT 33.5 22.7 HGF_HUMAN 33.3 20.2 PLMN_HUMAN 31.9 21 FA10_BOVIN 31.6 19.4 C1S_HUMAN 31.6 19.6 FA9_HUMAN 31.4 20.8 C1R_HUMAN 31.3 20.3 UROK_MOUSE 30.7 20 FA7_HUMAN 30.6 19.7 SYFB_HUMAN 30.6 17.4 CFAB_HUMAN 30.5 19.7 Q5U2Q5_RAT 30 16.6 PROC_HUMAN 29.6 20.2 UROK_HUMAN 29.5 18.7 BTK_HUMAN 29.4 15.5 ERO1_YEAST 29.3 16.9 GLSK_RAT 29.3 17.5 VMAT2_HUMAN 29.3 16.1 RIR1_HUMAN 28.8 16 SAP_HUMAN 28.8 17.6 MDM2_HUMAN 28.8 17.7 Q5PY49_HUMAN 28.3 18.4 ACES_TORCA 28.2 16.9 SPTC3_MOUSE 28.2 15.4 enlarge table
Protein-Protein Interactions:	Uniprot name Source TFPI2_HUMAN PMID 8555184 IPSP_HUMAN 2 PMIDs FA11_HUMAN 3 PMIDs enlarge table

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