Target Details

Name:	Cytochrome P450 2C18
Uniprot name:	CP2CI_HUMAN
Accession Numbers:	B2R8K2 P33260 Q16703 Q16751 Q6GRG1
EC-Number:	1.14.14.1
Organism:	Homo sapiens Human
PDB IDs:	2H6P
KEGG Pathways:	show KEGG Pathways
Drugs:	Name PubChem ID Source References Interaction BUPRENORPHINE 40400 SuperCyp PMID 15743975 show Buprenorphine 5311033 SuperCyp PMID 15743975 show CHEMBL120183 10861208 BindingDB - show CHEMBL120426 10938696 BindingDB - show CHEMBL120797 10894740 BindingDB - show CHEMBL120825 10861641 BindingDB - show CHEMBL121040 44346781 BindingDB - show CHEMBL121048 11123454 BindingDB - show CHEMBL121241 11732429 BindingDB - show CHEMBL121323 11100382 BindingDB - show CHEMBL121420 11103028 BindingDB - show CHEMBL121503 10950401 BindingDB - show CHEMBL121522 11070834 BindingDB - show CHEMBL330871 11078396 BindingDB - show CHEMBL331431 11133137 BindingDB - show CHEMBL331485 11046887 BindingDB - show CHEMBL332690 10895263 BindingDB - show CHEMBL332994 11013215 BindingDB - show CHEMBL333108 10916150 BindingDB - show CHEMBL333210 10938153 BindingDB - show CHEMBL333704 10948187 BindingDB - show CHEMBL414238 10045582 BindingDB - show CHEMBL432386 10245060 BindingDB - show CHEMBL443542 10925491 BindingDB - show Chlorepin 2789 SuperCyp PMID 15483195 show Chlorperphenazine 4748 SuperCyp PMID 11136295 show CLOTIAZEPAM 2811 SuperCyp PMID 16141545 show Cyclophosphoramide 2907 SuperCyp PMID 10348794 show dexlansoprazole 3883 PROMISCUOUS PMID 12612455 show dexlansoprazole 3883 SuperCyp PMID 7870052 show Dextromethadone 4095 SuperCyp PMID 8839037 show Dextromethadone 643985 SuperCyp PMID 8839037 show Diaminodiphenylsulfone 2955 SuperCyp PMID 10901692 show Dichlofenac 3033 PROMISCUOUS 3 PMIDs show Dichlofenac 3033 SuperCyp 2 PMIDs show Diethylparaoxon 9395 SuperTarget - show Diisopropylphenol 4943 PROMISCUOUS PMID 9764927 show Diisopropylphenol 4943 SuperCyp PMID 9771309 show Dimethylaminophenyldimethylpyrazolone 6009 PROMISCUOUS PMID 11853173 show Dimethylaminophenyldimethylpyrazolone 6009 SuperCyp PMID 10199594 show Dimethyloxyquinazine 2206 SuperCyp PMID 8681486 show Diphenylhydatanoin 1775 PROMISCUOUS 2 PMIDs show Diphenylhydatanoin 1775 SuperCyp PMID 11996015 show Dipropylacetate 3121 SuperCyp PMID 9606477 show DMZ 447297 BindingDB - show Esomeprazole 4594 SuperCyp PMID 8894508 show Isophosphamide 3690 SuperCyp PMID 10348794 show Lidocaine Monohydrochloride 3676 PROMISCUOUS PMID 15845683 show Lidocaine Monohydrochloride 3676 SuperCyp 2 PMIDs show Methylaminopropyliminodibenzyl 2995 SuperCyp PMID 9884317 show Methyldiazepinone 3016 SuperCyp PMID 9028867 show Norchlorimipramine 3696 SuperCyp PMID 9190854 show Rattentraenke 6691 SuperCyp PMID 7704034 show Sulfaphenylpyrazole 5335 BindingDB - show Tolylsulfonylbutylurea 5505 PROMISCUOUS PMID 14973304 show Tolylsulfonylbutylurea 5505 SuperCyp PMID 11996015 show Triacetyloleandomycin 202225 PROMISCUOUS 4 PMIDs show Triacetyloleandomycin 202225 SuperCyp PMID 15054565 show Trichloraethylenum 6575 SuperTarget - show enlarge table
Synonyms:	CYPIIC18 Cytochrome P450 2C18 P450-6B/29C enlarge table
Similar targets:	Uniprot name % Sequence similarity % Sequence identity CP2CJ_HUMAN 91.8 81 Q5VX92_HUMAN 91.6 81.8 CP2C9_HUMAN 91.6 81.8 CP2C5_RABIT 88.6 77.3 CP2C6_RAT 88.4 77.1 CP2C8_HUMAN 87.6 77.1 CP2CB_RAT 86.4 75.6 CP2E1_HUMAN 74.3 56.5 Q3YA63_HUMAN 74.3 56.5 Q6NWT7_HUMAN 74.1 56.3 Q6NWT9_HUMAN 73.9 56.1 CP2B4_RABIT 70.7 50.1 CP2B1_RAT 70.7 51.1 CP2F1_HUMAN 70.5 51.3 CP2B6_HUMAN 69 47.9 CP2A6_HUMAN 68.9 48.7 CP2AD_HUMAN 68.4 49.3 CP2A7_HUMAN 68.2 47.7 CP2A5_MOUSE 68.2 49.5 Q16743_HUMAN 65.5 58.6 CP2S1_HUMAN 61.5 42.3 CP2D1_RAT 58.1 39 CP2W1_HUMAN 58.1 38 Q6NWU0_HUMAN 58 38.6 CP2D6_HUMAN 58 38.6 Q38LG0_HUMAN 57.8 38.4 Q38LG2_HUMAN 57.8 38.2 CP2J2_HUMAN 56.9 37.2 Q6XP50_HUMAN 54.4 36.1 Q14097_HUMAN 52.7 36.9 enlarge table
Protein-Protein Interactions:	No data available enlarge table

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