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Drug-Target Interaction

Drug

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PubChem ID:945
Structure:
Synonyms:
10102-43-9
14332-28-6
51005-20-0
51005-21-1
53851-19-7
90452-29-2
90880-94-7
AC1L1ADQ
AC1Q6QZ0
Amidogen, oxo-
AR-1K7463
Bioxyde d'azote
Bioxyde d'azote [French]
CCRIS 4319
CHEMBL1234765
D009569
EINECS 233-271-0
Endogenous Nitrate Vasodilator
Endothelium-Derived Nitric Oxide
HNO
HSDB 1246
INOmax
LS-192158
LS-7547
Mononitrogen monoxide
Monoxide, Mononitrogen
Monoxide, Nitrogen
Nitrate Vasodilator, Endogenous
nitric oxide
Nitric oxide 10% by volume or more
Nitric oxide, compressed [UN1660] [Poison gas]
Nitric oxide, compressed [UN1660] [Poison gas]
Nitric Oxide, Endothelium Derived
Nitric Oxide, Endothelium-Derived
NITRIC-OXIDE
nitrogen monoxide
Nitrogen oxide
Nitrogen oxide (NO)
nitrogen protoxide
Nitrosyl hydride
Nitrosyl hydride ((NO)H)
Nitroxide radical
Nitroxyl
NMO
NO
Oxide, Nitric
Oxyde nitrique [French]
RCRA waste no. P076
RCRA waste number P076
Stickmonoxyd
Stickmonoxyd [German]
UN 1660
UN1660
UNII-31C4KY9ESH
Vasodilator, Endogenous Nitrate
ATC-Codes:

Target

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Uniprot ID:A3LNE3_PICST
Synonyms:
Aldehyde dehydrogenase
EC-Numbers:1.2.1.3
1.2.1.9
Organism:Pichia stipitis
Yeast
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

1433175
Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase.. M J Lee; H T Nagasawa; J A Elberling; E G DeMaster (1992) Journal of medicinal chemistry display abstract
In the preceding paper, analogs of chlorpropamide with an OMe substituent on the sulfonamide nitrogen were shown to inhibit aldehyde dehydrogenase (AlDH), and it was postulated that these compounds were bioactivated by O-demethylation to release nitroxyl (HN = O, nitrosyl hydride), which is an inhibitor of AlDH. Further evidence for the production of nitroxyl from compounds with O-acyl instead of OMe on the sulfonamide nitrogen is now presented. Thus, nitrous oxide (N2O), the end product of nitroxyl dimerization and disproportionation, was found to be generated on alkaline or enzymatic hydrolysis of N,O-diacylated N-hydroxyarylsulfonamides. Since the latter compounds strongly inhibit yeast AlDH in vitro after bioactivation by an esterase intrinsic to this enzyme, nitroxyl generated from these compounds must be the common intermediate that inhibits AlDH.