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Drug-Target Interaction

Drug

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PubChem ID:9395
Structure:
Synonyms:
311-45-5
36186_FLUKA
36186_RIEDEL
4-06-00-01327 (Beilstein Handbook Reference)
AC1L1SY4
AI3-16087
Bio-0720
BRN 1915526
c0088
C06606
C10H14NO6P
CCRIS 7780
CHEBI:27827
CHEMBL23838
Chinorta
Chinorto
D010261
D9286_SIGMA
Diaethyl-p-nitrophenylphosphorsaeureester
Diaethyl-p-nitrophenylphosphorsaeureester [German]
diethyl (4-nitrophenyl) phosphate
Diethyl 4-nitrophenyl phosphate
Diethyl p Nitrophenyl Phosphate
Diethyl p-nitrophenyl phosphate
Diethyl paraoxon
Diethyl-p-nitrofenyl ester kyseliny fosforecne
Diethyl-p-nitrofenyl ester kyseliny fosforecne [Czech]
Diethyl-p-nitrophenyl phosphate
Diethylparaoxon
E 600
E 600 (pesticide)
E-600
E600
EINECS 206-221-0
ENT 16,087
Ester 25
Ethyl p-nitrophenyl ethylphosphate
Ethyl paraoxan
Ethyl paraoxon
Eticol
Fosfakol
HC 2072
HSDB 6044
LS-107729
Mintaco
Mintacol
Mintisal
Miotisal
Miotisal A
NCGC00164276-01
NCGC00164276-02
nchembio.86-comp17
NSC 404110
NSC404110
O,O'Diaethyl-p-nitrophenylphosphat
O,O'Diaethyl-p-nitrophenylphosphat [German]
O,O-Diethyl O-(4-nitrophenyl) phosphate
O,O-Diethyl O-4-nitrophenyl phosphate
O,O-Diethyl O-p-nitrophenyl phosphate
O,O-Diethyl phosphoric acid O-p-nitrophenyl ester
O,O-Diethyl-O-p-nitrophenylphosphoric acid
O,O-diethyl-O-p-nitrophenylphosphoric acid, diethyl-p-nitrophenyl
O,O-diethyl-O-p-nitrophenylphosphoric acid, diethyl-p-nitrophenyl phosphate
O,O-Dietyl-O-p-nitrofenylfosfat
O,O-Dietyl-O-p-nitrofenylfosfat [Czech]
Oxyparathion
p-Nitrophenyl diethyl phosphate
p-Nitrophenyl diethylphosphate
Paraoxon
Paraoxon-ethyl
Paraoxone
Paroxan
Pestox 101
Phenol, p-nitro-, ester with diethyl phosphate
Phosphachole
Phosphacol
Phosphakol
Phosphate, Diethyl-p-Nitrophenyl
Phosphonothioic acid, diethylparanitrophenyl ester
Phosphoric acid diethyl 4-nitrophenyl ester
Phosphoric acid, diethyl 4-nitrophenyl ester
Phosphoric acid, diethyl p-nitrophenyl ester
PS610_SUPELCO
RCRA waste no. P041
RCRA waste number P041
Soluglacit
Soluglaucit
STOCK1S-32982
TS 219
WLN: WNR DOPO & O2 & O2
ZINC01530487
ATC-Codes:

Target

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Uniprot ID:O35535_RAT
Synonyms:
Carboxylesterase
EC-Numbers:3.1.1.1
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

8160210
An investigation of activities and paraoxon sensitivities of hepatic aliesterases in beta-naphthoflavone-treated rats.. A M Watson; H Chambers; J E Chambers (1994) Toxicology letters display abstract
Aliesterases (carboxylesterases, EC 3.1.1.1) are serine esterases which may protect acetylcholinesterase during organophosphorus insecticide intoxication by providing alternative phosphorylation sites. Levels of hepatic aliesterase activity were investigated after the intraperitoneal administration of beta-naphthoflavone (BNF) to female rats using nine 4-nitrophenyl esters as substrates (including straight and branched chain aliphatic and aromatic esters) and 1-naphthyl acetate. In addition, the in vitro sensitivities of aliesterases to inhibition by paraoxon, the active metabolite of the common insecticide parathion, were studied. Hepatic aliesterases from BNF-treated rats displayed lower activities than those from the controls with all substrates except 4-nitrophenyl phenylbutyrate and isovalerate. The aliesterases from BNF-treated rats were more sensitive to paraoxon inhibition with 4-nitrophenyl phenylbutyrate, valerate, and butyrate. Esterases hydrolyzing 4-nitrophenyl butyrate, valerate, and branched chain esters were most sensitive to paraoxon inhibition while those hydrolyzing 4-nitrophenyl hexanoate and aromatic esters were least sensitive. The results suggested that BNF-induced changes in hepatic aliesterases could alter responses to organophosphates.