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Drug-Target Interaction

Drug

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PubChem ID:9395
Structure:
Synonyms:
311-45-5
36186_FLUKA
36186_RIEDEL
4-06-00-01327 (Beilstein Handbook Reference)
AC1L1SY4
AI3-16087
Bio-0720
BRN 1915526
c0088
C06606
C10H14NO6P
CCRIS 7780
CHEBI:27827
CHEMBL23838
Chinorta
Chinorto
D010261
D9286_SIGMA
Diaethyl-p-nitrophenylphosphorsaeureester
Diaethyl-p-nitrophenylphosphorsaeureester [German]
diethyl (4-nitrophenyl) phosphate
Diethyl 4-nitrophenyl phosphate
Diethyl p Nitrophenyl Phosphate
Diethyl p-nitrophenyl phosphate
Diethyl paraoxon
Diethyl-p-nitrofenyl ester kyseliny fosforecne
Diethyl-p-nitrofenyl ester kyseliny fosforecne [Czech]
Diethyl-p-nitrophenyl phosphate
Diethylparaoxon
E 600
E 600 (pesticide)
E-600
E600
EINECS 206-221-0
ENT 16,087
Ester 25
Ethyl p-nitrophenyl ethylphosphate
Ethyl paraoxan
Ethyl paraoxon
Eticol
Fosfakol
HC 2072
HSDB 6044
LS-107729
Mintaco
Mintacol
Mintisal
Miotisal
Miotisal A
NCGC00164276-01
NCGC00164276-02
nchembio.86-comp17
NSC 404110
NSC404110
O,O'Diaethyl-p-nitrophenylphosphat
O,O'Diaethyl-p-nitrophenylphosphat [German]
O,O-Diethyl O-(4-nitrophenyl) phosphate
O,O-Diethyl O-4-nitrophenyl phosphate
O,O-Diethyl O-p-nitrophenyl phosphate
O,O-Diethyl phosphoric acid O-p-nitrophenyl ester
O,O-Diethyl-O-p-nitrophenylphosphoric acid
O,O-diethyl-O-p-nitrophenylphosphoric acid, diethyl-p-nitrophenyl
O,O-diethyl-O-p-nitrophenylphosphoric acid, diethyl-p-nitrophenyl phosphate
O,O-Dietyl-O-p-nitrofenylfosfat
O,O-Dietyl-O-p-nitrofenylfosfat [Czech]
Oxyparathion
p-Nitrophenyl diethyl phosphate
p-Nitrophenyl diethylphosphate
Paraoxon
Paraoxon-ethyl
Paraoxone
Paroxan
Pestox 101
Phenol, p-nitro-, ester with diethyl phosphate
Phosphachole
Phosphacol
Phosphakol
Phosphate, Diethyl-p-Nitrophenyl
Phosphonothioic acid, diethylparanitrophenyl ester
Phosphoric acid diethyl 4-nitrophenyl ester
Phosphoric acid, diethyl 4-nitrophenyl ester
Phosphoric acid, diethyl p-nitrophenyl ester
PS610_SUPELCO
RCRA waste no. P041
RCRA waste number P041
Soluglacit
Soluglaucit
STOCK1S-32982
TS 219
WLN: WNR DOPO & O2 & O2
ZINC01530487
ATC-Codes:

Target

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Uniprot ID:LIPG_BOVIN
Synonyms:
Gastric lipase
Gastric triacylglycerol lipase
GL
PGE
Pregastric esterase
EC-Numbers:3.1.1.3
Organism:Bos taurus
Bovine
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

8615791
Inhibition studies on calf pregastric esterase: the enzyme has no functional thiol group.. M Y Timmermans; G Reekmans; H J Teuchy; L P Kupers (1996) The Biochemical journal display abstract
Pregastric esterase (PGE) (EC 3.1.1.3) was purified to homogeneity from calf pharyngeal tissue. The enzyme had an apparent molecular mass of 50 kDa, as determined by SDS/PAGE. The serine-binding reagent diethyl p-nitrophenyl phosphate was a potent inhibitor of PGE. This is in accordance with the claim that a functional serine residue is necessary for the lipolytic activity of lipases. PGE was not inhibited by the thiol reagents 5,5'-dithiobis(2-nitrobenzoic acid) or 4,4'-dithiopyridine. A partial inhibition with dodecyldithio-5-(2-nitrobenzoic acid) was observed, but the same degree of inhibition was caused by the non-esterified fatty acid C(12:0). PGE shows a great sequence similarity to gastric lipases. Gastric lipases have three cysteine residues, and two of these form a disulphide bridge. Blocking the remaining free cysteine with thiol reagents inactivates the gastric lipases. The fact that PGE is not inhibited by thiol reagents indicates that PGE has no functional free thiol group. The PGE cDNA codes only for two cysteines, and their involvement in the formation of a disulphide bridge was demonstrated.