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Drug-Target Interaction

Drug

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PubChem ID:9395
Structure:
Synonyms:
311-45-5
36186_FLUKA
36186_RIEDEL
4-06-00-01327 (Beilstein Handbook Reference)
AC1L1SY4
AI3-16087
Bio-0720
BRN 1915526
c0088
C06606
C10H14NO6P
CCRIS 7780
CHEBI:27827
CHEMBL23838
Chinorta
Chinorto
D010261
D9286_SIGMA
Diaethyl-p-nitrophenylphosphorsaeureester
Diaethyl-p-nitrophenylphosphorsaeureester [German]
diethyl (4-nitrophenyl) phosphate
Diethyl 4-nitrophenyl phosphate
Diethyl p Nitrophenyl Phosphate
Diethyl p-nitrophenyl phosphate
Diethyl paraoxon
Diethyl-p-nitrofenyl ester kyseliny fosforecne
Diethyl-p-nitrofenyl ester kyseliny fosforecne [Czech]
Diethyl-p-nitrophenyl phosphate
Diethylparaoxon
E 600
E 600 (pesticide)
E-600
E600
EINECS 206-221-0
ENT 16,087
Ester 25
Ethyl p-nitrophenyl ethylphosphate
Ethyl paraoxan
Ethyl paraoxon
Eticol
Fosfakol
HC 2072
HSDB 6044
LS-107729
Mintaco
Mintacol
Mintisal
Miotisal
Miotisal A
NCGC00164276-01
NCGC00164276-02
nchembio.86-comp17
NSC 404110
NSC404110
O,O'Diaethyl-p-nitrophenylphosphat
O,O'Diaethyl-p-nitrophenylphosphat [German]
O,O-Diethyl O-(4-nitrophenyl) phosphate
O,O-Diethyl O-4-nitrophenyl phosphate
O,O-Diethyl O-p-nitrophenyl phosphate
O,O-Diethyl phosphoric acid O-p-nitrophenyl ester
O,O-Diethyl-O-p-nitrophenylphosphoric acid
O,O-diethyl-O-p-nitrophenylphosphoric acid, diethyl-p-nitrophenyl
O,O-diethyl-O-p-nitrophenylphosphoric acid, diethyl-p-nitrophenyl phosphate
O,O-Dietyl-O-p-nitrofenylfosfat
O,O-Dietyl-O-p-nitrofenylfosfat [Czech]
Oxyparathion
p-Nitrophenyl diethyl phosphate
p-Nitrophenyl diethylphosphate
Paraoxon
Paraoxon-ethyl
Paraoxone
Paroxan
Pestox 101
Phenol, p-nitro-, ester with diethyl phosphate
Phosphachole
Phosphacol
Phosphakol
Phosphate, Diethyl-p-Nitrophenyl
Phosphonothioic acid, diethylparanitrophenyl ester
Phosphoric acid diethyl 4-nitrophenyl ester
Phosphoric acid, diethyl 4-nitrophenyl ester
Phosphoric acid, diethyl p-nitrophenyl ester
PS610_SUPELCO
RCRA waste no. P041
RCRA waste number P041
Soluglacit
Soluglaucit
STOCK1S-32982
TS 219
WLN: WNR DOPO & O2 & O2
ZINC01530487
ATC-Codes:

Target

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Uniprot ID:CP2E1_HUMAN
Synonyms:
4-nitrophenol 2-hydroxylase
CYPIIE1
Cytochrome P450 2E1
P450-J
EC-Numbers:1.14.13.-
1.14.13.n7
Organism:Homo sapiens
Human
PDB IDs:3E4E 3E6I
Structure:
3E6I

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----

References:

8615874
Interaction of ethanol and the organophosphorus insecticide parathion.. J A O'Shaughnessy; L G Sultatos (1995) Biochemical pharmacology display abstract
Phosphorothioate insecticides such as parathion (O,O-diethyl-O-p-nitrophenyl phosphorothioate) undergo P450-dependent oxidative desulfuration, leading to both activation and detoxification of these compounds. Consequently, alterations in P450-dependent oxidative desulfuration may affect the acute toxicities of these insecticides. In the present study, pretreatment of mice with 15% ethanol in the drinking water for 6 days antagonized the acute toxicity of parathion, but not its toxic metabolite paraoxon (O,O-diethyl-O-p-nitrophenyl phosphate), suggesting that ethanol affected the oxidative desulfuration of this insecticide. The presence of ethanol within hepatic microsomal incubations did not alter the P450-dependent formation of paraoxon (activation) and p-nitrophenol (detoxification), although p-nitrophenol levels were increased in the presence of ethanol as a result of inhibition of its biotransformation to 4-nitrocatechol by CYP2E1. Ethanol exposure reduced hepatic pyruvate levels, but had no effect on levels of lactate, isocitrate, alpha-ketoglutarate, and malate. Calculation of cytosolic NAD+/NADH and cytosolic NADP+/NADPH redox ratios did not reveal any detectable difference in redox state between control and ethanol-treated mice. Since ethanol did not alter directly the P450-dependent activation or detoxification of parathion, and did not decrease NADPH levels, ethanol's antagonism of the acute toxicity of parathion may result from reduced availability of O2.
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