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Drug-Target Interaction

Drug

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PubChem ID:9395
Structure:
Synonyms:
311-45-5
36186_FLUKA
36186_RIEDEL
4-06-00-01327 (Beilstein Handbook Reference)
AC1L1SY4
AI3-16087
Bio-0720
BRN 1915526
c0088
C06606
C10H14NO6P
CCRIS 7780
CHEBI:27827
CHEMBL23838
Chinorta
Chinorto
D010261
D9286_SIGMA
Diaethyl-p-nitrophenylphosphorsaeureester
Diaethyl-p-nitrophenylphosphorsaeureester [German]
diethyl (4-nitrophenyl) phosphate
Diethyl 4-nitrophenyl phosphate
Diethyl p Nitrophenyl Phosphate
Diethyl p-nitrophenyl phosphate
Diethyl paraoxon
Diethyl-p-nitrofenyl ester kyseliny fosforecne
Diethyl-p-nitrofenyl ester kyseliny fosforecne [Czech]
Diethyl-p-nitrophenyl phosphate
Diethylparaoxon
E 600
E 600 (pesticide)
E-600
E600
EINECS 206-221-0
ENT 16,087
Ester 25
Ethyl p-nitrophenyl ethylphosphate
Ethyl paraoxan
Ethyl paraoxon
Eticol
Fosfakol
HC 2072
HSDB 6044
LS-107729
Mintaco
Mintacol
Mintisal
Miotisal
Miotisal A
NCGC00164276-01
NCGC00164276-02
nchembio.86-comp17
NSC 404110
NSC404110
O,O'Diaethyl-p-nitrophenylphosphat
O,O'Diaethyl-p-nitrophenylphosphat [German]
O,O-Diethyl O-(4-nitrophenyl) phosphate
O,O-Diethyl O-4-nitrophenyl phosphate
O,O-Diethyl O-p-nitrophenyl phosphate
O,O-Diethyl phosphoric acid O-p-nitrophenyl ester
O,O-Diethyl-O-p-nitrophenylphosphoric acid
O,O-diethyl-O-p-nitrophenylphosphoric acid, diethyl-p-nitrophenyl
O,O-diethyl-O-p-nitrophenylphosphoric acid, diethyl-p-nitrophenyl phosphate
O,O-Dietyl-O-p-nitrofenylfosfat
O,O-Dietyl-O-p-nitrofenylfosfat [Czech]
Oxyparathion
p-Nitrophenyl diethyl phosphate
p-Nitrophenyl diethylphosphate
Paraoxon
Paraoxon-ethyl
Paraoxone
Paroxan
Pestox 101
Phenol, p-nitro-, ester with diethyl phosphate
Phosphachole
Phosphacol
Phosphakol
Phosphate, Diethyl-p-Nitrophenyl
Phosphonothioic acid, diethylparanitrophenyl ester
Phosphoric acid diethyl 4-nitrophenyl ester
Phosphoric acid, diethyl 4-nitrophenyl ester
Phosphoric acid, diethyl p-nitrophenyl ester
PS610_SUPELCO
RCRA waste no. P041
RCRA waste number P041
Soluglacit
Soluglaucit
STOCK1S-32982
TS 219
WLN: WNR DOPO & O2 & O2
ZINC01530487
ATC-Codes:

Target

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Uniprot ID:ABD12_CHICK
Synonyms:
2-arachidonoylglycerol hydrolase
Abhydrolase domain-containing protein 12
Monoacylglycerol lipase ABHD12
EC-Numbers:3.1.1.23
Organism:Chicken
Gallus gallus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

3995049
The relationship between the carboxylesterase and monoacylglycerol lipase activities of chicken liver microsomes.. D T Keough; J de Jersey; B Zerner (1985) Biochimica et biophysica acta display abstract
The carboxylesterase (carboxylic-ester hydrolase, EC 3.1.1.1) and monoacylglycerol lipase (glycerol-monoester acylhydrolase, EC 3.1.1.23) activities, measured against ethyl butyrate and emulsified monooleoylglycerol respectively, were determined for chicken liver microsomes and highly purified chicken liver carboxylesterase. The activity ratio (ethyl butyrate activity/monooleoylglycerol activity) was approx. 5 for microsomes and approx. 400 for carboxylesterase. Homogenization of microsomes in 0.1 M Tris-HCl buffer (pH 7.92) released all of the ethyl butyrate activity and about half of the monooleoylglycerol activity into a soluble form. Both activities eluted from a Sephadex G-200 column with the same elution volume as that of pure carboxylesterase. This fraction (fraction B) had an activity ratio of approx. 15, an average pI of 5.01 (cf. 4.75 for carboxylesterase), and ran on polyacrylamide gel electrophoresis at pH 8.6 as a number of closely spaced esterase bands with mobilities considerably less than those of the esterase bands present in the carboxylesterase. Fraction B activities against both substrates were completely inhibited by diethyl p-nitrophenyl phosphate and completely precipitated by antibody to carboxylesterase. The remaining half of the monoacylglycerol lipase activity of microsomes was solubilized by treatment with 1.5% (w/v) Triton X-100. This solubilized monoacylglycerol lipase was completely inhibited by diethyl p-nitrophenyl phosphate, showing it to be a serine-dependent enzyme like the carboxylesterases. However, it had no detectable activity against ethyl butyrate, indicating that it is not closely related to the carboxylesterases.