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Drug-Target Interaction

Drug

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PubChem ID:7697
Structure:
Synonyms:
1,2-Propanediol, 3-(4-chlorophenoxy)-
1,2-Propanediol, 3-(4-chlorophenoxy)- (9CI)
1,2-Propanediol, 3-(p-chlorophenoxy)-
104-29-0
2-Chlorphenesin
3-(4-Chlorophenoxy)-1,2-propanediol
3-(4-chlorophenoxy)propane-1,2-diol
3-(p-Chlorophenoxy)-1,2-propanediol
3-(p-Chlorophenoxy)propane-1,2-diol
3-p-Chlorophenoxy-1,2-propanediol
4-06-00-00831 (Beilstein Handbook Reference)
AC-266
AC1L1PCF
AC1Q3ON1
AC1Q7BR5
Adermykon
AI3-24623
AKOS005203039
alpha-Glyceryl ether
AR-1K9771
BRN 2210845
C07928
C9H11ClO3
CHEBI:3642
Chlorophenesin
Chlorphenesin
Chlorphenesin [INN:BAN]
Chlorphenesine
Chlorphenesine [INN-French]
Chlorphenesinum
Chlorphenesinum [INN-Latin]
Clorfenesina
Clorfenesina [INN-Spanish]
DB00856
Demykon
EINECS 203-192-6
Gechophen
Gecophen
Glycerol .alpha.-p-chlorophenyl ether
Glycerol alpha-p-chlorophenyl ether
LS-120277
Maybridge1_000170
MixCom1_000324
Mycil
NCGC00160584-01
NSC 6401
NSC6401
Oprea1_755443
p-Chlorophenyl
p-chlorophenyl a-glyceryl ether
p-Chlorophenyl glyceryl ether
p-Chlorophenyl-.alpha.-glyceryl ether
p-Chlorophenyl-alpha-glyceryl ether
SBB015061
ST075161
UNII-I670DAL4SZ
WLN: Q1YQ1OR DG
ATC-Codes:

Target

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Uniprot ID:CNRG_CAVPO
Synonyms:
GMP-PDE gamma
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
EC-Numbers:3.1.4.17
Organism:Cavia porcellus
Guinea pig
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

187130
Interactions of chlorphenesin and divalent metal ions with phosphodiesterase.. J Edelson; J P McMullen (1976) Archives internationales de pharmacodynamie et de thérapie display abstract
Chlorphenesin inhibition of the hydrolysis of cyclic AMP by guinea-pig lung phosphodiesterase was reversed by the addition of exogenous magnesium ions. Chlorphenesin and theophylline inhibition of this enzyme was shown to be noncompetitive when the substrate concentration was low. Kinetic studies of the inhibition of beef heart phosphodiesterase by chlorphenesin and theophylline indicated that the substrate concentration was a factor in determining whether inhibition was competitive or noncompetitive. Calcium, cobalt and copper ions were inhibitory to guinea-pig lung phosphodiesterase. The inhibition due to chlorphenesin was partially reversed by low (40 mM or less) concentrations of barium ions; high concentrations of barium ions, or manganese ions, were inhibitory. The concentration of the divalent cation did not affect the type of inhibition that was observed.