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Drug-Target Interaction

Drug

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PubChem ID:73364
Structure:
Synonyms:
117591-20-5
Benzyl N-[(1S)-3-methyl-1-[[(2S)-1-oxohexan-2-yl]carbamoyl]butyl]carbamate
Benzylcarbonyl-leu-nleu-H
Bio2_000238
Bio2_000718
BSPBio_001518
C11256
C20H30N2O4
Calpeptin
Carbamic acid, (1-(((1-formylpentyl)amino)carbonyl)-3-methylbutyl)-,
Carbamic acid, (1-(((1-formylpentyl)amino)carbonyl)-3-methylbutyl)-, phenylemthyl ester, (S-(R*,R*))-
Carbamic acid, (1-(((1-formylpentyl)amino)carbonyl)-3-methylbutyl)-, phenylmethyl ester, (S-(R*,R*))-
CPD0-1359
IDI1_033988
KBio2_000238
KBio2_002806
KBio2_005374
KBio3_000475
KBio3_000476
KBioGR_000238
KBioSS_000238
LS-172355
N-Cbz-leu-nleu-al
n2-[(benzyloxy)carbonyl]-n-[(2s)-1-oxohexan-2-yl]-l-leucinamide
NCGC00024594-01
NCGC00163432-01
NCGC00163432-02
nchembio.79-comp26
Tocris-0448
ZINC03871838

Target

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Uniprot ID:Q9UBT1_HUMAN
Synonyms:
Estrogen receptor
EC-Numbers:-
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

8687127
Possible involvement of calpain in the growth of estrogen receptor positive breast cancer cells.. E Shiba; S Kim; M Fujitani; J I Kambayashi; I Kawamura; S Tsujimoto; K Shimomura; Y Tanji; T Taguchi; Y Kimoto; M Izukura; S I Takai (1996) Anticancer research display abstract
Calpain (Ca2(+)-activated neutral protease, EC 3.4.22.17) has been reported to hydrolyze the estrogen receptor (ER). However, there has been no report available regarding the role of calpain in the growth of breast cancer cells. To investigate the role of calpain in the growth of various breast cancer cell lines, we employed a synthetic peptide, calpeptin, which is a cell permeable specific inhibitor of calpain. Calpeptin inhibited the cell growth of ER positive breast cancer cells, such as MCF-7, T-47D, and ZR-75-1 in a dose dependent manner in the presence of E2. However, the growth of ER negative breast cancer cells, MDA-MB-231, was not inhibited by calpeptin. It is suggested that calpain plays an important role in the growth of ER positive breast cancer cells.