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Drug-Target Interaction

Drug

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PubChem ID:68841
Structure:
Synonyms:
()-l-serine dihydrogen phosphate (ester)
(+)-L-Serine dihydrogen phosphate (ester)
(2S)-2-amino-3-(phosphonooxy)propanoic acid
(2S)-2-amino-3-phosphonooxypropanoic acid
(S)-2-amino-3-hydroxypropanoic acid 3-phosphate
3-O-Phosphoserine
3-Phosphoserine
407-41-0
68762-59-4
AC1L2AK1
AC1Q6RUY
AR-1K9233
ARK086
bmse000399
C01005
CCG-204968
CHEBI:15811
CHEMBL284377
DB04522
Dexfosfoserine
Dexfosfoserine [INN]
EINECS 206-986-0
EU-0100886
F1EE42DE-E913-4F09-A97B-F539EE869AB7
Fosforina
HMS3262B14
HMS3264A13
L-2-amino-3-hydroxypropanoic acid 3-phosphate
L-3-Phosphoserine
L-O-Phosphoserine
L-O-Serine phosphate
L-Phosphoserine
L-Serine O-phosphate
L-Serine, dihydrogen phosphate (ester) (9CI)
L-serine, O-phosphono-
L-Serinephosphoric acid
L-Seryl phosphate
L-SOP
Lopac0_000886
LS-184497
NCGC00024512-01
NCGC00024512-02
NCGC00024512-03
NCGC00024512-04
NCGC00024512-05
NCGC00024512-06
O-Phospho-L-serine
O-phosphono-L-serine
o-Phosphonoserine
O-Phosphoryl-L-serine
O-Phosphorylserine
O-Phosphoserine
O3-phosphoserine
P 0878
P0773
P0878_SIGMA
Phosphatidalserine
Phospho-L-serine
PHOSPHONOSERINE
Phosphoserine
SEP
Serine dihydrogen phosphate (ester)
Serine O-phosphate
serine phosphate ester
Serine phosphate, L- (6CI)
Serine, dihydrogen phosphate (ester), L- (8CI)
Serine, O-phospho-
Tocris-0238

Target

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Uniprot ID:GRM4_HUMAN
Synonyms:
Metabotropic glutamate receptor 4
mGluR4
EC-Numbers:-
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
---1000
---1300

References:

17884634
A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation.. Jonathan P Saxe; Hao Wu; Theresa K Kelly; Michael E Phelps; Yi E Sun; Harley I Kornblum; Jing Huang (2007) Chemistry & biology display abstract
High-throughput identification of small molecules that selectively modulate molecular, cellular, or systems-level properties of the mammalian brain is a significant challenge. Here we report the chemical genetic identification of the orphan ligand phosphoserine (P-Ser) as an enhancer of neurogenesis. P-Ser inhibits neural stem cell/progenitor proliferation and self-renewal, enhances neurogenic fate commitment, and improves neuronal survival. We further demonstrate that the effects of P-Ser are mediated by the group III metabotropic glutamate receptor 4 (mGluR4). siRNA-mediated knockdown of mGluR4 abolished the effects of P-Ser and increased neurosphere proliferation, at least in part through upregulation of mTOR pathway activity. We also found that P-Ser increases neurogenesis in human embryonic stem cell-derived neural progenitors. This work highlights the tremendous potential of developing effective small-molecule drugs for use in regenerative medicine or transplantation therapy.