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Drug-Target Interaction

Drug

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PubChem ID:6435893
Structure:
Synonyms:
30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,
30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
79217-60-0
Ciclosporin
Cyclosporin
Cyclosporin A
CYCLOSPORINE
DB00091
LS-58836
Restasis
Sandimmune, Gengraf, Restasis, Atopica, Sangcya, Cyclosporine
ATC-Codes:

Target

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Uniprot ID:PPIA_HUMAN
Synonyms:
Cyclophilin A
Cyclosporin A-binding protein
Peptidyl-prolyl cis-trans isomerase A
PPIase A
Rotamase A
EC-Numbers:5.2.1.8
Organism:Homo sapiens
Human
PDB IDs:1AK4 1AWQ 1AWR 1AWS 1AWT 1AWU 1AWV 1BCK 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1FGL 1M63 1M9C 1M9D 1M9E 1M9F 1M9X 1M9Y 1MF8 1MIK 1NMK 1OCA 1RMH 1VBS 1VBT 1W8L 1W8M 1W8V 1YND 1ZKF 2ALF 2CPL 2CYH 2RMA 2RMB 3CYH 3CYS 4CYH 5CYH
Structure:
5CYH

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: