Drug-Target Interaction

Drug

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PubChem ID:

5394

Structure:

Synonyms:

3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide

3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide

3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide

3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetraazine-8-carboxamide

3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one

85622-93-1

AIDS-129717

AIDS129717

BRN 5547136

C047246

C6H6N6O2

CCRG 81045

CCRG-81045

CCRIS 8996

CPD000466338

D06067

DB00853

Essex brand of temozolomide

Imidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide,

Imidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide, 3,4-dihydro-3-methyl-4-oxo-

Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3,4-dihydro-3-methyl-4-oxo-

LS-80558

M & B 39831

M&B 39831

M&B-39831

MB 39831

Methazolastone

MLS000759447

MLS001424028

NCGC00167429-01

NCGC00167429-02

NCI60_003316

NSC 362856

NSC-362856

NSC362856

SAM001246636

Sch 52365

Sch-52365

Schering brand of temozolomide

Schering-Plough brand of temozolomide

SMR000466338

STOCK6S-53841

Temodal

Temodal (TN)

Temodar

Temozolamide

Temozolodida [Spanish]

Temozolomide

Temozolomide (JAN/USAN/INN)

Temozolomide [BAN:INN]

Temozolomide [INN:BAN]

Temozolomidum [Latin]

TL8005593

ZINC01482184

{Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide,} 3, 4-dihydro-3-methyl-4-oxo-

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ATC-Codes:

L01AX03

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Side-Effects:

Side-Effect	Frequency
lymphopenia	0.546053
confusion	0.0
insomnia	0.0
weight increase	0.0
infection viral	0.0
urinary tract infection	0.0
upper respiratory tract infection	0.0
sinusitis	0.0
pharyngitis	0.0
rash	0.0
diplopia	0.0
coughing	0.0
convulsions	0.0
pancytopenia	0
palpitations	0
peripheral edema	0
petechiae	0
ischemia	0
dyspepsia	0
dermatitis	0
dysphagia	0
anemia	0
thrombophlebitis	0
anorexia	0
sensory disturbance	0
somnolence	0
infection	0
connective tissue disorders	0
erythema multiforme	0
constitutional symptoms	0
heart disease	0
urinary frequency	0
clotting	0
weakness	0
aphasia	0
paresthesia	0
toxic epidermal necrolysis	0
deafness	0
cerebral hemorrhage	0
stomatitis	0
dry skin	0
abnormal gait	0
vascular disorders	0
sgot increased	0
cerebral ischemia	0
influenza	0
mediastinal disorders	0
constipation	0
amnesia	0
anxiety	0
breast disorders	0
breast pain	0
dry eyes	0
abnormal pigmentation	0
neuropathy	0
myalgia	0
arthralgia	0
hallucinations	0
increased sweating	0
dysuria	0
headache	0
behavior disorder	0
emotional lability	0
apathy	0
vomiting	0
hearing loss	0
vaginal hemorrhage	0
glioma	0
nasal congestion	0
otitis media	0
amenorrhea	0
thrombocytopenia	0
hemorrhage	0
status epilepticus	0
neutropenia	0
dehydration	0
abdominal distention	0
myelogenous leukemia	0
abdominal pain	0
dysphasia	0
dyspnea	0
abnormal vision	0
memory impairment	0
myelodysplastic syndrome	0
visual field defect	0
pain	0
fecal incontinence	0
herpes simplex	0
tooth disorder	0
nausea	0
pneumocystis carinii pneumonia	0
alopecia	0
photosensitivity	0
menorrhagia	0
musculoskeletal pain	0
hypokalemia	0
deep vein thrombosis	0
flushing	0
infertility	0
cancer	0
hemiplegia	0
gastroenteritis	0
erythema	0
agitation	0
back pain	0
ear pain	0
hyperacusis	0
fever	0
impotence	0
stevens - johnson syndrome	0
urinary incontinence	0
hypertension	0
pruritus	0
eye pain	0
transient ischemic attack	0
dry mouth	0
aplastic anemia	0
leukopenia	0
pneumonia	0
concentration impaired	0
seizures	0
moniliasis	0
intracranial hemorrhage	0
myopathy	0
herpes zoster	0
anaphylaxis	0
pulmonary embolism	0
embolism	0
tremor	0
hemiparesis	0
hot flashes	0
peripheral neuropathy	0
malaise	0
allergic reaction	0
bronchitis	0
tinnitus	0
diarrhea	0
blurred vision	0
purpura	0
hyperesthesia	0
alkaline phosphatase increased	0
hyperglycemia	0
hemorrhoids	0
edema	0
dizziness	0
ataxia	0
vaginitis	0
fatigue	0
endocrine disorders	0
muscle weakness	0
asthenia	0
vertigo	0
weight loss	0

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Target

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Uniprot ID:

ICE_DROME

Synonyms:

Caspase

drICE

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EC-Numbers:

3.4.22.-

Organism:

Drosophila melanogaster
Fruit fly

PDB IDs:

Binding Affinities:

Ki:	Kd:	Ic 50:	Ec50/Ic50:
-	-	-	-

References:

11912174
Prevention of irradiation-induced glioma cell invasion by temozolomide involves caspase 3 activity and cleavage of focal adhesion kinase.. Wolfgang Wick; Antje Wick; Jörg B Schulz; Johannes Dichgans; Hans P Rodemann; Michael Weller (2002) Cancer research display abstract

Sublethal doses of irradiation enhance the invasiveness of human malignantglioma cells. This can be inhibited by subtoxic concentrations of temozolomide (TMZ) but not by lomustine. Antagonism of irradiation-induced motility by TMZ is associated with the prevention of irradiation-induced alpha(v)beta(3)-integrin, matrix metalloproteinase-2 and MT1-matrix metalloproteinase-expression. Irradiation induces focal adhesion kinase (FAK) activation by phosphorylation, whereas TMZ promotes FAK cleavage. Inhibition of caspases prevents TMZ-induced FAK processing and restores the promigratory effect of irradiation, suggesting that the resistance of glioma cells to irradiation-induced caspase processing may determine the invasive responses of glioma cells to irradiation. In contrast, DAOY medulloblastoma cells, which respond with caspase activation to irradiation alone, do not show enhanced invasiveness when irradiated.