Drug-Target Interaction

Drug

show drug details

PubChem ID:

444732

Structure:

Synonyms:

(2E,4E,6R)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

(2E,4E,6R)-7-(4-Dimethylaminophenyl)-N-hydroxy-4,6-dimethyl-7-oxo-hepta-2,4-dienamide

(2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide

(R)-Trichostatin A

1c3r

2,4-Heptadienamide,

2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-

2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)-

2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)-

2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)- (9CI)

2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, [R-(E,E)]-

58880-19-6

7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide

7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDE

A 300

A-300-I

AIDS-096139

AIDS096139

Antibiotic A-300

C17H22N2O3

CHEBI:46024

LMPK01000055

LS-74195

NCGC00162453-01

NCGC00162453-02

NCGC00162453-03

NCGC_TSA

nchembio.147-comp4

NChemBio.2007.18-comp3

nchembio815-comp20

nchembio852-compR31

nchembio860-comp3

SGCTO-002

T8552_SIGMA

Trichlostatin A

Trichostatin A

Trichostatin A (TSA)

Trichostatin A from Streptomyces sp.

Tricostatin A

TSA

TSA, Trichostatin A

TSN

[R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

enlarge table

Target

show target details

Uniprot ID:

ICE_DROME

Synonyms:

Caspase

drICE

enlarge table

EC-Numbers:

3.4.22.-

Organism:

Drosophila melanogaster
Fruit fly

PDB IDs:

Binding Affinities:

Ki:	Kd:	Ic 50:	Ec50/Ic50:
-	-	-	-

References:

19013432
Suppression of caspase-11 expression by histone deacetylase inhibitors.. Hyejung Heo; Lang Yoo; Ki Soon Shin; Shin Jung Kang (2009) Biochemical and biophysical research communications display abstract

It has been well documented that histone deacetylase inhibitors suppress inflammatory gene expression. Therefore, we investigated whether histone deacetylase inhibitors modulate the expression of caspase-11 that is known as an inducible caspase regulating both inflammation and apoptosis. In the present study, we show that sodium butyrate and trichostatin A, two structurally unrelated inhibitors of histone deacetylase (HDAC), effectively suppressed the induction of caspase-11 in mouse embryonic fibroblasts stimulated with lipopolysaccharides. Sodium butyrate inhibited the activation of upstream signaling events for the caspase-11 induction such as activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase, degradation of inhibitor of kappaB, and activation of nuclear factor-kappaB. These results suggest that the HDAC inhibitor suppressed cytosolic signaling events for the induction of caspase-11 by inhibiting the deacetylation of non-histone proteins.