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Drug-Target Interaction

Drug

show drug details
PubChem ID:3100
Structure:
Synonyms:
1,4-Methanocycloocta[d]pyridazine, 1,4,4a,5,6,9,10,10a-octahydro-11,11-dimethyl-, (1.alpha.,4.alpha.,4a.alpha.,10a.alpha.)-
147-24-0
147-24-0 (HYDROCHLORIDE)
2-(Benzhydryloxy)-N,N-dimethylethylamine
2-(Benzhydryloxy)-N,N-dimethylethylamine, hydrochloride
2-(diphenylmethoxy)-N,N-dimethylethanamine
2-(Diphenylmethoxy)-N,N-dimethylethylamine
2-benzhydryloxy-N,N-dimethylethanamine
2-benzhydryloxyethyl-N,N-dimethylammonium
2-diphenylmethoxy-N,N-demthylethanamine
2-Diphenylmethoxy-N,N-dimethylethylamine
2-[(diphenylmethyl)oxy]-N,N-dimethylethanamine
2-[di(phenyl)methoxy]-N,N-dimethylethanamine
2PM
4-10-00-00125 (Beilstein Handbook Reference)
58-73-1
88637-37-0
88637-37-0 (citrate (1:1))
AB00053460
AC-13704
AC1L1F65
AIDS-018608
AIDS018608
AKOS003658554
Aleryl
Alledryl
Aller-Med
Allerdryl
Allergan B
Allergeval
Allergical
Allergina
Allergival
Allermax Caplets
alpha-(2-Dimethylaminoethoxy)diphenylmethane
Amidryl
Antistominum
Antitussive
Antomin
Automin
Bagodryl
Banophen
Banophen Caplets
Baramine
Beldin
Belix
Ben-allergin
Bena
Benachlor
Benadrin
Benadryl
Benadryl (hydrochloride)
Benadryl Allergy
BENADRYL HCl
Benapon
Benhydramin
Benodin
Benodine
Benylan
Benylin
Benzantine
Benzhydramine
Benzhydraminum
Benzhydril
Benzhydroamina
Benzhydryl
beta-Dimethylamino-aethyl-benzhydryl-aether
beta-Dimethylamino-aethyl-benzhydryl-aether [German]
beta-Dimethylaminoethanol diphenylmethyl ether
beta-dimethylaminoethyl benzhydryl ether
beta-Dimethylaminoethylbenzhydrylether
Betramin
BIDD:GT0152
BPBio1_000275
BRD-K47278471-003-05-7
BRN 1914136
BSPBio_000249
BSPBio_002219
C06960
C17H21NO
CAS-147-24-0
CCG-204472
CCRIS 1959
CHEBI:127629
CHEBI:4636
CHEMBL657
Compoz
CPD-10890
D00300
Dabylen
DB01075
DB06975
Debendrin
Dermistina
Dermodrin
Desentol
Diabenyl
Diabylen
Dibendrin
Dibenil
Dibondrin
Difedryl
Difenhidramina
Difenhidramina [INN-Spanish]
Difenhydramin
Difenidramina
Difenidramina [Italian]
Dihidral
Dimedrol
Dimedrol base
Dimedryl
Dimehydrinate
Diphantine
Diphen
Diphen Cough
Diphenhist
Diphenhist Captabs
DIPHENHYDRAMINE
Diphenhydramine (JP15/INN)
Diphenhydramine (JP16/INN)
Diphenhydramine Base
Diphenhydramine Citrate
Diphenhydramine Hcl
Diphenhydramine Hydrochloride
Diphenhydramine Salicylate
Diphenhydramine [INN:BAN:JAN]
DIPHENHYDRAMINE, ANTISTOMINUM, BENZHYDRAMINE
Diphenhydraminum
Diphenhydraminum [INN-Latin]
Diphenylhydramin
Diphenylhydramine
DivK1c_000368
Dormarex 2
Dryistan
Drylistan
Dylamon
EINECS 200-396-7
Etanautine
Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-
Ethylamine, 2-(diphenylmethoxy)-N,N-dimethyl-
Ethylamine, N,N-dimethyl-2-(diphenylmethoxy)-
FAR 90X2
Genahist
Histaxin
HMS2089E06
HMS2230L19
HSDB 3066
Hyadrine
Hydramine
Hyrexin
I14-6749
Ibiodral
IDI1_000368
KBio1_000368
KBio2_001460
KBio2_004028
KBio2_006596
KBio3_001439
KBioGR_001099
KBioSS_001460
L000227
Lopac-D-3630
Lopac0_000377
LS-68208
Medidryl
Mephadryl
MLS002222276
N,N-Dimethyl-2-(diphenylmethoxy)-ethylamine hydrochloride
N-(2-(Diphenylmethoxy)ethyl)-N,N-dimethylamine
N-(Benzhydryloksy-etylo)dwumetyloamina
N-(Benzhydryloksy-etylo)dwumetyloamina [Polish]
N-[2-(BENZHYDRYLOXY)ETHYL]-N,N-DIMETHYLAMINE
Nausen
NCGC00015335-01
NCGC00015335-02
NCGC00015335-03
NCGC00015335-04
NCGC00015335-05
NCGC00015335-06
NCGC00015335-07
NCGC00015335-08
NCGC00015335-09
NCGC00015335-10
NCGC00015335-11
NCGC00015335-12
NCGC00015335-13
NCGC00015335-14
NCGC00024414-03
NCGC00024414-04
NCGC00024414-05
NCGC00024414-06
nchembio747-comp18
NCI60_002916
NCI60_022782
Nervine Nighttime Sleep-Aid
NINDS_000368
Novamina
NSC665800
Nytol Quickcaps
Nytol Quickgels
O-Benzhydryldimethylaminoethanol
Oprea1_254625
PM 255
Prestwick0_000065
Prestwick1_000065
Prestwick2_000065
Prestwick3_000065
Probedryl
Restamin
Restamin (TN)
Rigidil
Rigidyl
S51
Siladryl
Silphen
Sleep-Eze D
Sleep-Eze D Extra Strength
SMR001307259
SPBio_000961
SPBio_002170
Spectrum2_000961
Spectrum3_000400
Spectrum4_000520
Spectrum5_000915
Spectrum_000980
ST024741
STK103720
STOCK2S-94461
Syntedril
Syntodril
TL8003758
Twilite Caplets
UNII-8GTS82S83M
Unisom Sleepgels Maximum Strength
[2-(diphenylmethoxy)ethyl]dimethylamine
ATC-Codes:
Side-Effects:
Side-EffectFrequency
diarrhea0
drug eruption0
tinnitus0
vomiting0
hypotension0
palpitations0
urinary retention0
convulsions0
diplopia0
nausea0
anorexia0
photosensitivity0
tremor0
somnolence0
labyrinthitis0
neuritis0
headache0
euphoria0
vertigo0
paresthesia0
sweating0
constipation0
agitation0
nasal congestion0
blurred vision0
chills0
thrombocytopenia0
nervousness0
confusion0
wheezing0
dizziness0
hemolytic anemia0
agranulocytosis0
urinary frequency0
anemia0
fatigue0
tachycardia0
insomnia0
irritability0

Target

show target details
Uniprot ID:Q38LG2_HUMAN
Synonyms:
Cytochrome P450 2D6
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

11270914
Diphenhydramine alters the disposition of venlafaxine through inhibition of CYP2D6 activity in humans.. E Lessard; M A Yessine; B A Hamelin; C Gauvin; L Labbé; G O'Hara; J LeBlanc; J Turgeon (2001) Journal of clinical psychopharmacology display abstract
CYP2D6 is the major enzyme involved in the metabolism of venlafaxine. Subjects with a low CYP2D6 activity have increased plasma concentrations of venlafaxine that may predispose them to cardiovascular side effects. In vitro and in vivo studies showed that diphenhydramine, a nonprescription antihistamine, can inhibit CYP2D6 activity. Therefore, the authors investigated in this study a potential drug interaction between diphenhydramine and venlafaxine. Fifteen male volunteers, nine with the extensive metabolizer (EM) and six with the poor metabolizer (PM) phenotype of CYP2D6, received venlafaxine hydrochloride 18.75 mg orally every 12 hours for 48 hours on two occasions (1 week apart): once alone and once during the concomitant administration of diphenhydramine hydrochloride (50 mg every 12 hours). Blood and urine samples were collected for 12 hours under steady-state conditions. In EMs, diphenhydramine decreased venlafaxine oral clearance from 104+/-60 L/hr to 43+/-23 L/hr (mean +/- SD; p < 0.05) without any effect on renal clearance (4+/-1 L/hr during venlafaxine alone and 4+/-2 L/hr during venlafaxine plus diphenhydramine). In PMs, coadministration of diphenhydramine did not cause significant changes in oral clearance and partial metabolic clearances of venlafaxine to its various metabolites. Diphenhydramine disposition was only slightly affected by genetically determined low CYP2D6 activity or concomitant administration of venlafaxine. In conclusion, diphenhydramine, at therapeutic doses, inhibits CYP2D6-mediated metabolism of venlafaxine in humans. Clinically significant interactions could be encountered during the concomitant administration of diphenhydramine and other antidepressant or antipsychotic drugs that are substrates of CYP2D6.