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Drug-Target Interaction

Drug

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PubChem ID:2955
Structure:
Synonyms:
"sulfona;diaminodiphenylsulfone;4-aminophenylsulfone"
(4-sulfanilylphenyl)amine
1,1'-Sulfonylbis(4-aminobenzene)
1,1'-Sulfonylbis[4-aminobenzene]
1,1'-Sulphonylbis(4-aminobenzene)
1358F
32960_FLUKA
4,4 inverted
4,4 inverted exclamation marka-Diaminodiphenyl sulfone
4,4' Diaminophenyl Sulfone
4,4'-Dapsone
4,4'-Diaminodiphenyl sulfone
4,4'-Diaminodiphenyl suphone
4,4'-Diaminodiphenylsulfone
4,4'-diaminophenyl sulfone
4,4'-Sulfonylbisaniline
4,4'-Sulfonylbisbenzamine
4,4'-Sulfonylbisbenzenamine
4,4'-Sulfonyldianiline
4,4'-Sulfonyldianiline (Dapsone)
4,4'-Sulphonylbisbenzamine
4,4'-Sulphonylbisbenzenamine
4,4'-Sulphonyldianiline
4,4-Diaminodifenylsulfon
4,4-Diaminodifenylsulfon [Czech]
4,4-Sulfonyldianiline
4-(4-aminophenyl)sulfonylaniline
4-13-00-01306 (Beilstein Handbook Reference)
4-Aminop henyl sulfone
4-Aminophenyl sulfone
4-Aminophenylsulfone
4-[(4-aminobenzene)sulfonyl]aniline
4-[(4-aminophenyl)sulfonyl]aniline
46158_FLUKA
46158_RIEDEL
80-08-0
A74807_ALDRICH
AB00051962
AB1004833
AC-10922
AC1L1EUH
AC1Q51WM
AC1Q51WN
Acedapsone
Aczone
Aczone (TN)
AG-H-21104
AI3-08087
AIDS-005738
AIDS005738
AKOS000119322
ALBB-005917
Ambap3158
Ambap80-08-0
Aniline, 4,4'-sulfonyldi-
Araldite HT
Araldite HT 976
Atrisone
Avlosulfon
Avlosulfone
Avlosulphone
Avsulfor
AZT + Dapsone cominbation
BBL002412
Benzenamine, 4,4'-sulfonylbis-
BIDD:GT0770
Bis(4-aminophenyl) sulfone
Bis(4-aminophenyl)sulfone
Bis(4-aminophenyl)sulphone
Bis(p-aminophenyl) sulfone
Bis(p-aminophenyl)sulphone
BPBio1_000143
BRD-K62363391-001-05-8
BRN 0788055
BSPBio_000129
BSPBio_002129
C07666
C12H12N2O2S
CAS-80-08-0
CBDivE_013582
CCG-40260
CCRIS 192
CHEBI:4325
CHEMBL1043
CPD000059064
Croysulfone
Croysulphone
D SS
D003622
D00592
D0089
DADPS
Dapsoderm-X
Dapson
Dapson-Fatol
Dapsona
Dapsona [INN-Spanish]
Dapsone
Dapsone (USP)
Dapsone [USAN:BAN]
Dapsonum
Dapsonum [INN-Latin]
DB00250
DDS
DDS (pharmaceutical)
Dds, Diaphenylsulfone
DDS, pharmaceutical
Di(4-aminophenyl) sulfone
Di(4-aminophenyl)sulfone
Di(4-aminophenyl)sulphone
Di(p-aminophenyl) sulfone
Di(p-aminophenyl)sulphone
Diamino-4,4'-diphenyl sulfone
Diamino-4,4'-diphenyl sulphone
Diamino-diphenyl sulphone
Diaminodifenilsulfona
Diaminodifenilsulfona [Spanish]
Diaminodiphenyl sulfone
Diaminodiphenylsulfone
Diaphenylsulfon
Diaphenylsulfone
Diaphenylsulfone (JAN)
Diaphenylsulphon
Diaphenylsulphone
Diphenasone
Diphone
Disulone
DivK1c_000573
DRG-0036
DSS
DSS (VAN)
Dubronax
Dubronaz
Dumitone
EINECS 201-248-4
Eporal
F 1358
Fatol Brand of Dapsone
Hardener HT 976
HMS1568G11
HMS1920C14
HMS2091K04
HMS2095G11
HMS2231G09
HMS3259C13
HMS501M15
HSDB 5073
HT 976
HY 976
I01-3640
ICI
IDI1_000573
IN-201
KBio1_000573
KBio2_001368
KBio2_003936
KBio2_006504
KBio3_001349
KBioGR_000900
KBioSS_001368
LS-1790
Metabolite C
Mex-America Brand of Dapsone
MLS000069409
MLS001055349
MLS001076146
N'-Diphenyl sulfondiamide
N, N'-Diphenyl Sulfondiamide
N,N'-Diphenyl sulfondiamide
NCGC00016322-01
NCGC00016322-02
NCGC00016322-03
NCGC00016322-04
NCGC00016322-05
NCGC00016322-06
NCGC00016322-07
NCGC00016322-08
NCGC00016322-09
NCGC00016322-10
NCGC00023946-03
NCGC00023946-04
NCGC00023946-05
NCGC00023946-06
NCI-C01718
NINDS_000573
Novophone
NSC 6091
NSC 6091D
NSC-6091
NSC6091
Oprea1_143052
Orsade Brand of Dapsone
P, P'-Sulfonyldianiline
p,p'-Diaminodiphenyl sulfone
p,p'-Sulfonyldianiline
p,p-Diaminodiphenyl sulphone
p,p-Sulfonylbisbenzamine
p,p-Sulfonylbisbenzenamine
p,p-Sulphonylbisbenzamine
p,p-Sulphonylbisbenzenamine
p,p-Sulphonyldianiline
p-Aminophenyl sulfone
Prestwick0_000035
Prestwick1_000035
Prestwick2_000035
Prestwick3_000035
Prestwick_152
Protogen
SAM002554879
SBB003168
Slphadione
SMR000059064
SPBio_001025
SPBio_002050
SPECTRUM1500222
Spectrum2_001133
Spectrum3_000375
Spectrum4_000310
Spectrum5_000825
Spectrum_000888
STK387118
Sulfadione
Sulfanona-mae
sulfon-mere
Sulfona
Sulfona-MAE
Sulfona;Diaminodiphenylsulfone;4-Aminophenylsulfone
Sulfone UCB
Sulfone, 4,4'-Diaminophenyl
Sulfone, diphenyl, 4,4'-diamino-
Sulfonyldianiline
Sulphadione
Sulphon-mere
Sulphonyldianiline
Sumicure S
Tarimyl
TL8005401
Udolac
UNII-8W5C518302
W R 448
WLN: ZR DSWR DZ
WR 448
ZINC00006310
ATC-Codes:
Side-Effects:
Side-EffectFrequency
erythema0.067999996
nasopharyngitis0.05
headache nos0.04
cough0.02
sinusitis nos0.02
pharyngitis0.02
pruritus0.01
influenza0.01
pyrexia0.01
suicide attempt0
vomiting0
pancreatitis0
abdominal pain0
swelling0

Target

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Uniprot ID:DYR_HUMAN
Synonyms:
Dihydrofolate reductase
EC-Numbers:1.5.1.3
Organism:Homo sapiens
Human
PDB IDs:1BOZ 1DHF 1DLR 1DLS 1DRF 1HFP 1HFQ 1HFR 1KMS 1KMV 1MVS 1MVT 1OHJ 1OHK 1PD8 1PD9 1PDB 1S3U 1S3V 1S3W 1U71 1U72 1YHO 2C2S 2C2T 2DHF 3EIG 3F8Y 3F8Z 3F91 3FS6 3GHC 3GHV 3GHW
Structure:
3GHW

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: