Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug-Target Interaction

Drug

show drug details
PubChem ID:2378
Structure:
Synonyms:
(+)-1-(p,alpha-diphenylbenzyl)imidazole
(+)1-([1,1'-biphenyl]-4-ylphenylmethyl)-1h-imidazole
(+-)-1-(p,alpha-Diphenylbenzyl)imidazole
(+-)1-([1,1'-Biphenyl]-4-ylphenylmethyl)-1H-imidazole
1-((4-Biphenylyl)phenylmethyl)-1H-imidazole
1-(alpha-(4-Biphenylyl)benzyl)imidazole
1-(Biphenyl-4-yl-phenyl-methyl)-1H-imidazole
1-(p,alpha-Diphenylbenzyl)imidazole
1-[4,alpha-Diphenylbenzyl]-imidazole
1-[biphenyl-4-yl(phenyl)methyl]-1H-imidazole
1-[phenyl-(4-phenylphenyl)methyl]imidazole
1H-Imidazole, 1-((1,1'-biphenyl)-4-ylphenylmethyl)-
1h-imidazole, 1-((1,1'-biphenyl)-4-ylphenylmethyl)-, (+)-
1H-Imidazole, 1-((1,1'-biphenyl)-4-ylphenylmethyl)-, (+-)-
1H-Imidazole, 1-([1,1'-biphenyl]-4-ylphenylmethyl)-
5-23-04-00292 (Beilstein Handbook Reference)
60628-96-8
AC-15414
AC1L1DJN
AIDS-009214
AIDS009214
Amycor
Azolmen
BAY H 4502
Bay H-4502
Bay-h-4502
Bayer brand of bifonazole
Bifokey
Bifomyk
Bifon
Bifonazol
Bifonazol [INN-Spanish]
BIFONAZOLE
Bifonazole (JP15/USAN/INN)
Bifonazole (JP16/USAN/INN)
Bifonazole [USAN:BAN:INN:JAN]
Bifonazolum
Bifonazolum [INN-Latin]
Bio-0008
Bioglan brand of bifonazole
BRD-A94543220-001-02-3
BRN 0618427
BSPBio_003570
C036596
C22H18N2
Canesten brand of bifonazole
Canesten Extra Bifonazol
CCG-100993
CCG-39996
CHEBI:116973
CHEMBL277535
CPD000058970
D01775
DB04794
Dermapharm brand of bifonazole
EINECS 262-336-6
HMS1922B18
HMS2051F04
HMS2090K13
HMS2093B09
HMS2232J24
I01-2098
Imidazole, 1-(alpha-(4-biphenylyl)benzyl)-
Inkeysa brand of bifonazole
Juventus brand of bifonazole
KBio3_002922
LS-78073
Merck Lipha Sant? brand of bifonazole
MLS000028576
MLS000759537
MLS001074074
Moldina
Mycospor
Mycospor (TN)
NCGC00018254-02
NCGC00018254-03
NCGC00018254-04
NCGC00018254-05
NCGC00089815-02
NCGC00089815-03
NCGC00089815-04
SAM001246775
SMR000058970
SPBio_000129
SPECTRUM1505309
Spectrum2_000035
Spectrum3_001970
STK618771
STOCK6S-47881
TL8003842
Trifonazole
VU0239694-7
ATC-Codes:

Target

show target details
Uniprot ID:CP2E1_HUMAN
Synonyms:
4-nitrophenol 2-hydroxylase
CYPIIE1
Cytochrome P450 2E1
P450-J
EC-Numbers:1.14.13.-
1.14.13.n7
Organism:Homo sapiens
Human
PDB IDs:3E4E 3E6I
Structure:
3E6I

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----

References:

15135088
Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors.. Katalin Monostory; Eszter Hazai; Lszl Vereczkey (2004) Chemico-biological interactions display abstract
p-Nitrophenol hydroxylation is widely used as a probe for microsomal CYP2E1. Several drugs are known as CYP2E1 inhibitors because of their capability to inhibit p-nitrophenol hydroxylation. Our results suggest further participation of CYP2A6 and CYP2C19 enzymes in p-nitrophenol hydroxylation. Moreover, CYP2A6 and CYP2C19 may be considered as the primary catalysts, whereas CYP2E1 can also contribute to the hydroxylation of p-nitrophenol. Further aim of our study was to evaluate the selectivity of p-nitrophenol hydroxylase inhibitors towards cytochrome P450 enzymes. The effects of antifungals: bifonazole, econazole, clotrimazole, ketoconazole, miconazole; CNS-active drugs: chlorpromazine, desipramine, fluphenazine, thioridazine; and the non-steroidal anti-inflammatory drug: diclofenac were investigated on the enzyme activities selective for CYP2A6, CYP2C9, CYP2C19, CYP2E1 and CYP3A4. None of the drugs could be considered as a potent inhibitor of CYP2E1. Strong inhibition was observed for CYP3A4 by antifungals with IC(50) values in submicromolar range. However, ketoconazole was the only imidazole derivative that could be considered as a selective inhibitor of CYP3A4. The CNS-active drugs investigated were found to be weak inhibitors of CYP2A6, CYP2C9, CYP2C19, CYP2E1 and CYP3A4. Diclofenac efficiently inhibited CYP2C9 and to a less extent CYP3A4 enzyme.
9574817