Drug-Target Interaction

Drug

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PubChem ID:

2140

Structure:

Synonyms:

(Diacetyldiamine)triiodobenzoate

117-96-4

2,4,6-Triiodo-3,5-diacetamidobenzoic acid

3, 5-Diacetamido-2,4,6-triiodobenzoic

3, 5-Diacetamido-2,4,6-triiodobenzoic acid, sodium salt

3,5-Bis(acetamido)-2,4,6-triiodobenzoic Acid

3,5-Bis(acetylamino)-2,4,6-triiodobenzoic acid

3,5-Di(acetamido)-2,4,6-triiodobenzoic Acid

3,5-Diacetamido-2,4,6-triiodobenzoate

3,5-Diacetamido-2,4,6-triiodobenzoic acid

4-14-00-01308 (Beilstein Handbook Reference)

737-31-5 (SODIUM SALT)

AC-4695

AC1L1D0C

Acide amidotrizoique

Acidum amidotrizoicum

Acidum diacetylaminotrijodbenzoicum

AIDS-155966

AIDS155966

AKOS001073646

Amidotrizoate

Amidotrizoate (*sodium salt*)

AmiDOTrizoic acid

amidotrizoic acid (anhydrous)

Amidotrizoic acid (JP15)

Amidotrizoic acid (JP16)

Amidotrzoique (acide)

benzoate

Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-

Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-, monosodium salt

Benzoic acid, 3,5-diacetamido-2,4, 6-triiodo-, sodium salt

Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-

Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-, monosodium salt

BRN 2225144

CHEBI:53691

CHEMBL1201220

Conray 35

D02240

D1462

D9268_SIGMA

D9809_SIAL

DB00271

Diat

DIAT [German]

Diatriazoate

Diatrizoate

Diatrizoate sodium

Diatrizoate sodium salt

Diatrizoesaeure

Diatrizoesaure

Diatrizoesaure [German]

Diatrizoic acid

diatrizoic acid (anhydrous)

Diatrizoic acid (USP)

Diatrizoic acid dihydrate

Diatrizoic acid sodium salt

Diatrizoic acid [USAN:BAN]

EINECS 204-223-6

G 2-75

Gastrografin

HMS2094A11

HSDB 4042

Hypaque

Hypaque 50

Hypaque sodium

Iothalamate

LS-36713

MD-50

Meglumine diatrizoate

Methalamic acid

Ml 216

NCGC00021123-01

NCGC00021123-02

NSC 262168

NSC262168

NSC61815

NSC61815 (SODIUM SALT)

Odiston

Renografin 76

S 17

Sodium (diacetyldiamine)triiodobenzoate

Sodium 3,5-diacetamido-2,4,6-triiodobenzoate

Sodium amidotrizoate

Sodium diatrizoate

T0514-0244

Triombrin

Triombrin [Russian]

Triombrine

UNII-5UVC90J1LK

Urografic acid, sodium salt

Urografin acid

Urogranoic acid

Urotrast

Urovison

Vascoray

Win 8308-3

WLN: 1VMR BI DI FI CVQ EMV1

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ATC-Codes:

V08AA01

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Side-Effects:

Side-Effect	Frequency
paralysis	0
syncope	0
swelling	0
sweating	0
sneezing	0
shock	0
rhinitis	0
pulmonary embolism	0
pulmonary edema	0
pruritus	0
petechiae	0
paresthesia	0
weakness	0
numbness	0
neutropenia	0
tachycardia	0
thrombophlebitis	0
tremor	0
hypoxia	0
speech disturbance	0
sinus arrest	0
respiratory arrest	0
renal colic	0
agitation	0
sinus bradycardia	0
wheezing	0
vomiting	0
ventricular fibrillation	0
urticaria	0
uremia	0
erythema	0
unconsciousness	0
nephrosis	0
nausea	0
myocardial infarction	0
cough	0
conjunctivitis	0
confusion	0
coma	0
choking	0
chest pain	0
carcinoma	0
bronchospasm	0
asthma	0
arthralgia	0
arrhythmia	0
apnea	0
angioedema	0
anemia	0
diarrhea	0
dizziness	0
somnolence	0
transverse myelitis	0
leukopenia	0
acute tubular necrosis	0
hypertension	0
hypersensitivity	0
hemiparesis	0
hematuria	0
cardiac arrest	0
gangrene	0
flushing	0
flank pain	0
rash	0
edema	0
dyspnea	0
anaphylaxis	0

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Target

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Uniprot ID:

PLMN_HUMAN

Synonyms:

Plasminogen

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EC-Numbers:

3.4.21.7

Organism:

Homo sapiens
Human

PDB IDs:

1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2PK4 5HPG

Structure:

5HPG

Binding Affinities:

Ki:	Kd:	Ic 50:	Ec50/Ic50:
-	-	-	-

References:

11981110
An analysis of mechanisms underlying the antifibrinolytic properties of radiographic contrast agents.. P M Farrehi; Y Zhu; W P Fay (2001) Journal of thrombosis and thrombolysis display abstract

BACKGROUND: Radiographic contrast agents inhibit fibrinolysis, although by poorly defined pathways. The purpose of this study was to define specific mechanisms by which contrast agents inhibit clot lysis. METHODS AND RESULTS: Diatrizoate (high osmolar ionic agent), ioxaglate (low osmolar ionic), and ioversol (nonionic) were studied in vitro. Diatrizoate inhibited clot lysis by 81.3+/-0.6% vs. control (p0.3). Inhibition of fibrinolysis was not explained by the high osmolarities of contrast agents, by their iodine content, or by their effects on the amidolytic activities of t-PA, urokinase, or plasmin. However, plasminogen activation by t-PA, urokinase, or streptokinase was significantly inhibited by contrast agents. Diatrizoate, ioxaglate, and ioversol inhibited plasminogen binding to plasma clots by 51+/-4% (p