• TRPA-1

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    Detailed Information

    Name: TRPA1_HUMAN
    Recommended name: Transient receptor potential cation channel subfamily A member 1
    Alternative Names:
    • Ankyrin-like with transmembrane domains protein 1
    • Transformation-sensitive protein p120
    Pubmed: 23774285
    Uniprot ID: O75762
    Synonyms: ANKTM1
    Sequence length: 1119 AA.
    Enzyme regulation: Inhibited by ruthenium red, a potent blocker of TRPV channels
    BindingDB: O75762
    Kegg: hsa:8989
    Chembl: CHEMBL6007
    Prosite: PS50297
    Pfam: PF00023
    GeneID: 8989
    Ensembl: ENST00000262209
    Phosphosite: O75762
    RefSeq: NP_015628.2
    UniGene: 716816
    NIG genetics: TRPA1
    OMIM: 604775
    WikiGenes: 8989

    The transient receptor potential cation channel subfamily A member 1 (TRPA1) plays a key role in chemical sensing in inflammatory pain pathway. Many small molecules, including ingredients like wasabi, horseradish, garlic and mustard oil, can activate the channel. It has also been shown that some endogenous compounds could activate TRPA1.

    Recent studies identified various natural transient receptor potential cation channel subfamily A member 1 (TRPA1) agonists.

    TRPA1 is also essential for chemical sensing of oxidants and electrophilic agents in the airways. There is some evidence that TRPA1 reacts similar to a reactive airway irritant receptor. TRPA1 is permeable to calcium ions and blocked by ruthenium red, which is known to antagonize bronchoconstriction. It has also been found, that a pretreatment with capsaicin renders C-fibers insensitive to mustard oil, as well as chemical airway irritants. Mustard oil, which is the pungent ingredient in wasabi, is a potent upper airway irritant. Acrolein, methacrolein, methyl vinyl ketone, hypochlorite, and crotone aldehyde are also activators of TRPA1.