Show Compounds

    Detailed Information

    Name: KCNK2_HUMAN
    Recommended name: Potassium channel subfamily K member 2
    Alternative Names:
    • Outward rectifying potassium channel protein TREK-1
    • TREK-1 K(+) channel subunit
    • Two pore domain potassium channel TREK-1
    • Two pore potassium channel TPKC1
    Pubmed: 16675954
    Uniprot ID: O95069
    Synonyms: TREK, TREK1
    Sequence length: 426 AA.
    Kegg: hsa:3776
    Pfam: PF07885
    GeneID: 3776
    Ensembl: ENST00000391894
    Phosphosite: O95069
    RefSeq: NP_001017424.1
    UniGene: 497745
    OMIM: 603219
    WikiGenes: 3776
    IUPHAR: Trek

    The potassium channel, subfamily K, member 2 is a channel protein encoded by the KCNK2 gene. In small diameter sensory neurons TREK1 is often co-expressed with TRPV1.

    Structure and Function

    TREK-1 is formed by two homodimers, which lead potassium into the cell and therefore control the resting membrane potential. The carboxyl and amino termini are located at the intracellular site. It can be activated by certain anesthetics, membrane stretching, intracellular acidosis, heat or phospholipids, such as phosphatidylinositol. Because of its contribution to physiological, pathophysiological, and pharmacological processes, TREK-1 has a crucial role in the therapy of epilepsy, as well as brain and spinal chord ischemia. It is also been shown that membrane phospholipids like PIP2 control channel gating of TREK-1. If sensory neurons are stimulated with heat, the co-expression with TRPV1 leads to a modulation of TRPV1 activity therefore is an interesting target for pain management.

    These models are based on different template structures, which show sequence similarity to TREK-1.