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    CHEMBL209303



    Inhibition of:
    ASIC: 9 nM (ic50)
    Synonymous names
    CHEMBL209303
    CHEBI:452542
    SmilesC1=CC(=CC=C1CCCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N)OCC(CO)O
    10127538 
     
    16821771
    FormulaC19H26ClN7O4
    Molweight451.907
    Heavy Atoms31
    Rotatable Bonds11
    H-bond donors6
    H-bond Acceptors 9
    Cluster numberCluster75


    CHEMBL212410


    Show docking results

    Inhibition of:
    ASIC: 21 nM (ic50)
    Synonymous names
    CHEMBL212410
    CHEBI:452396
    SmilesC1=CC(=CC=C1CCCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N)N
    10237309 
     
    16821771
    FormulaC16H21ClN8O
    Molweight376.844
    Heavy Atoms26
    Rotatable Bonds7
    H-bond donors5
    H-bond Acceptors 7
    Cluster numberCluster75


    CHEMBL214239


    Show docking results

    Inhibition of:
    ASIC: 14 nM (ic50)
    Synonymous names
    CHEMBL214239
    CHEBI:452641
    SmilesC1=CC(=CC=C1CCCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N)CO
    10237531 
     
    16821771
    FormulaC17H22ClN7O2
    Molweight391.855
    Heavy Atoms27
    Rotatable Bonds8
    H-bond donors5
    H-bond Acceptors 7
    Cluster numberCluster75


    CHEMBL211161


    Show docking results

    Inhibition of:
    ASIC: 9 nM (ic50)
    Synonymous names
    CHEMBL211161
    CHEBI:452286
    SmilesC1=CC(=CC=C1CCCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N)OCCO
    10310039 
     
    16821771
    FormulaC18H24ClN7O3
    Molweight421.881
    Heavy Atoms29
    Rotatable Bonds10
    H-bond donors5
    H-bond Acceptors 8
    Cluster numberCluster75


    CHEMBL212432



    Inhibition of:
    ASIC: 8 nM (ic50)
    Synonymous names
    CHEMBL212432
    CHEBI:452327
    SmilesC1=CC(=CC=C1CCCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N)OCC(CO)O
    10310524 
     
    16821771
    FormulaC19H26ClN7O4
    Molweight451.907
    Heavy Atoms31
    Rotatable Bonds11
    H-bond donors6
    H-bond Acceptors 9
    Cluster numberCluster75


    CHEMBL211072


    Show docking results

    Inhibition of:
    ASIC: 42 nM (ic50)
    Synonymous names
    CHEMBL211072
    CHEBI:452142
    SmilesC1=CC(=C(C=C1CCCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N)O)O
    10385923 
     
    16821771
    FormulaC16H20ClN7O3
    Molweight393.828
    Heavy Atoms27
    Rotatable Bonds7
    H-bond donors6
    H-bond Acceptors 8
    Cluster numberCluster75


    CHEMBL211221


    Show docking results

    Inhibition of:
    ASIC: 64 nM (ic50)
    Synonymous names
    CHEMBL211221
    CHEBI:452283
    SmilesC1=CC(=CC=C1CCCCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N)O
    10430582 
     
    16821771
    FormulaC17H22ClN7O2
    Molweight391.855
    Heavy Atoms27
    Rotatable Bonds8
    H-bond donors5
    H-bond Acceptors 7
    Cluster numberCluster75


    Benzamil


    Show docking results

    Inhibition of:
    ASIC: 66 nM (ic50)
    Synonymous names
    Benzamil
    AC1L33CQ
    CHEMBL212579
    HMS1791O22
    HMS1361O22
    C13751
    HMS2090F10
    HMS1989O22
    GNF-Pf-192
    Lopac-B-2417
    BSPBio_003465
    BSPBio_001580
    BSPBio_000693
    KBioSS_000300
    KBioGR_000300
    Prestwick0_000657
    Spectrum3_001823
    NINDS_001001
    SPBio_002614
    Prestwick3_000657
    CHEBI:452516
    Prestwick2_000657
    Prestwick1_000657
    CCG-204306
    LS-184230
    KBio3_000599
    BPBio1_000763
    KBio2_005436
    KBio2_002868
    DivK1c_001001
    KBio2_000300
    Lopac0_000211
    KBio3_002969
    KBio1_001001
    KBio3_000600
    IDI1_034050
    Bio1_000361
    IDI1_001001
    Bio2_000780
    Bio2_000300
    Bio1_001339
    SMP1_000301
    Bio1_000850
    NCGC00162093-03
    2898-76-2
    NCGC00015147-04
    NCGC00162093-02
    NCGC00015147-03
    NCGC00162093-01
    NCGC00015147-02
    NCGC00015147-07
    NCGC00015147-01
    NCGC00015147-06
    NCGC00162093-04
    NCGC00015147-05
    N-(N-Benzylamidino)-3,5-diamino-6-chloropyrazine carboxamide
    3,5-Diamino-6-chloro-N-(imino((phenylmethyl)amino)methyl)pyrazinecarboxamide
    CAS-2898-76-2
    3,5-diamino-N-(N'-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide
    Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-(imino((phenylmethyl)amino)methyl)-
    BRD-K97688263-001-02-9
    BRD-K97688263-003-04-1
    2-Pyrazinecarboxamide, 3,5-diamino-N-[(1E)-amino[(phenylmethyl)amino]methylene]-6-chloro-, monohydrochloride
    SmilesC1=CC=C(C=C1)CN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N
    108107 
     
    16821771
    FormulaC13H14ClN7O
    Molweight319.75
    Heavy Atoms22
    Rotatable Bonds4
    H-bond donors4
    H-bond Acceptors 6
    Cluster numberCluster75


    SureCN5582867


    Show docking results

    Inhibition of:
    ASIC3: 9000 nM (ic50)
    Synonymous names
    CHEMBL1770730
    SureCN5582867
    CHEBI:1243034
    SmilesCC1=NC(=CC=C1)NC2=NC=CC3=C2OC=C3
    11160454 
     
    21257308
    FormulaC13H11N3O
    Molweight225.246
    Heavy Atoms17
    Rotatable Bonds2
    H-bond donors1
    H-bond Acceptors 4
    Cluster numberNo cluster with more than 3 Compounds available


    CHEMBL196536


    Show similar structuresShow docking results

    Inhibition of:
    Synonymous names
    CHEMBL196536
    SureCN5582792
    CHEBI:430185
    SmilesCC1=NC(=CC=C1)NC2=C(C=CC=N2)OC
    11413259 
     
    21257308
    FormulaC12H13N3O
    Molweight215.251
    Heavy Atoms16
    Rotatable Bonds3
    H-bond donors1
    H-bond Acceptors 4
    Cluster numberNo cluster with more than 3 Compounds available


    CHEMBL208620


    Show similar structuresShow docking results

    Inhibition of:
    ASIC: 58 nM (ic50)
    Synonymous names
    CHEMBL208620
    CHEBI:452393
    SmilesC1=CC=C(C=C1)CCCCCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N
    11495588 
     
    16821771
    FormulaC18H24ClN7O
    Molweight389.882
    Heavy Atoms27
    Rotatable Bonds9
    H-bond donors4
    H-bond Acceptors 6
    Cluster numberCluster75


    CHEMBL209104


    Show docking results

    Inhibition of:
    ASIC: 77 nM (ic50)
    Synonymous names
    CHEMBL209104
    CHEBI:452579
    SmilesCOC1=CC=C(C=C1)CCCCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N
    11509687 
     
    16821771
    FormulaC18H24ClN7O2
    Molweight405.882
    Heavy Atoms28
    Rotatable Bonds9
    H-bond donors4
    H-bond Acceptors 7
    Cluster numberCluster75


    CHEMBL210967


    Show docking results

    Inhibition of:
    ASIC: 124 nM (ic50)
    Synonymous names
    CHEMBL210967
    CHEBI:452461
    SmilesCOC1=CC=C(C=C1)CCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N
    11509869 
     
    16821771
    FormulaC16H20ClN7O2
    Molweight377.829
    Heavy Atoms26
    Rotatable Bonds7
    H-bond donors4
    H-bond Acceptors 7
    Cluster numberCluster75


    CHEMBL379756


    Show docking results

    Inhibition of:
    ASIC: 22 nM (ic50)
    Synonymous names
    CHEMBL379756
    CHEBI:452578
    SmilesCOC(=O)C1=CC=C(C=C1)CCCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N
    11509999 
     
    16821771
    FormulaC18H22ClN7O3
    Molweight419.865
    Heavy Atoms29
    Rotatable Bonds9
    H-bond donors4
    H-bond Acceptors 8
    Cluster numberCluster75


    CHEMBL211658


    Show docking results

    Inhibition of:
    ASIC: 28 nM (ic50)
    Synonymous names
    CHEMBL211658
    CHEBI:452263
    SmilesC1=CC=C(C(=C1)CCCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N)OCC(CO)O
    11510735 
     
    16821771
    FormulaC19H26ClN7O4
    Molweight451.907
    Heavy Atoms31
    Rotatable Bonds11
    H-bond donors6
    H-bond Acceptors 9
    Cluster numberCluster408


    CHEMBL208889


    Show docking results

    Inhibition of:
    ASIC: 31 nM (ic50)
    Synonymous names
    CHEMBL208889
    CHEBI:452479
    SmilesC1=CC=C(C(=C1)CCCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N)OCCO
    11510866 
     
    16821771
    FormulaC18H24ClN7O3
    Molweight421.881
    Heavy Atoms29
    Rotatable Bonds10
    H-bond donors5
    H-bond Acceptors 8
    Cluster numberCluster408


    CHEMBL214220


    Show docking results

    Inhibition of:
    ASIC: 25 nM (ic50)
    Synonymous names
    CHEMBL214220
    CHEBI:452613
    SmilesCOC1=CC=C(C=C1)OCCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N
    11524036 
     
    16821771
    FormulaC16H20ClN7O3
    Molweight393.828
    Heavy Atoms27
    Rotatable Bonds8
    H-bond donors4
    H-bond Acceptors 8
    Cluster numberCluster75


    CHEMBL212534


    Show docking results

    Inhibition of:
    ASIC: 26 nM (ic50)
    Synonymous names
    CHEMBL212534
    CHEBI:452581
    SmilesC1=CC(=CC(=C1)OCC(CO)O)CCCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N
    11525260 
     
    16821771
    FormulaC19H26ClN7O4
    Molweight451.907
    Heavy Atoms31
    Rotatable Bonds11
    H-bond donors6
    H-bond Acceptors 9
    Cluster numberCluster408


    CHEMBL209017


    Show docking results

    Inhibition of:
    ASIC: 48 nM (ic50)
    Synonymous names
    CHEMBL209017
    CHEBI:452443
    SmilesC1=CC(=CC=C1CCCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N)OCC(=O)O
    11525704 
     
    16821771
    FormulaC18H22ClN7O4
    Molweight435.865
    Heavy Atoms30
    Rotatable Bonds10
    H-bond donors5
    H-bond Acceptors 9
    Cluster numberCluster408


    CHEMBL209659


    Show docking results

    Inhibition of:
    ASIC: 29 nM (ic50)
    Synonymous names
    CHEMBL209659
    CHEBI:452354
    SmilesC1=CC=C(C=C1)CCCCN=C(N)NC(=O)C2=C(N=C(C(=N2)Cl)N)N
    11553041 
     
    16821771
    FormulaC16H20ClN7O
    Molweight361.829
    Heavy Atoms25
    Rotatable Bonds7
    H-bond donors4
    H-bond Acceptors 6
    Cluster numberCluster75