|Recommended name:||P2X purinoceptor 2|
|Sequence length:||471 AA.|
P2X receptors are trimeric ATP-activated to Na+, K+ and Ca2+. The seven subtypes play different roles in physiological processes, e.g. contraction of smooth muscle, regulation of immune responses and modulation of synaptic transmission. The study of these receptors has improved due to X-ray crystallography. Molecular modeling and in silico ligand docking allow the development of putative ligands.
Current (pre-)clinical studies investigate the involvement of P2X receptors in pain, inflammation, osteoporosis, multiple sclerosis, spinal cord injury, and bladder dysfunction. For the modulation of pain transmission, it has been shown that P2X3, as well as P2X2/3 are promising targets and selective antagonists may be useful analgesic drugs. Interestingly, in traditional Chinese medicine, tetramethylprazine, sodium ferrulate and puerarin are used in the therapy of pain. It has been found, that these compounds target P2X.