|Neurofascin (NF) is an interesting multidomain protein, which occurs in cell surface of neurons and glia. Alternative splicing provides four different isoforms with 186, 180, 166 and 155 kDa. This protein regulates several cell processes during the development of neurons and in the mature brain. These are processes like neurite outgrowth and the control of postsynaptic components or in the mature brain the stabilization of axo-axonic synapses, formation and stabilization of nodes of Ranvier and paranodes. The different isoforms have thereby a special function and show a distinct expression level during live time. For example, NF 186 is essential for the concentration and recruitment of the voltage-gated sodium channel 1.6 at nodes of Ranvier. Therefore NF directly interacts with two subunits (ß1,ß2) of the sodium channel.|
Interestingly, antibodies against Neurofascin were found in patients suffering from Multiple scleroses and Guillain-Barré syndrome.