SuperSweet is a knowledge base platform for about 15,000 natural and artificial sweeteners including information on their origin, sweetness class, glycemic index, year of approval, predicted toxicity profile as well as possible molecular targets. SuperSweet is not only a comprehensive knowledge base for existing carbohydrates and artificial sweeteners but also includes a homology modelled sweet taste receptor and docked binders. In the current version of the SuperSweet database, a data visualization platform for commonly used sweeteners called sweetoscope has been implemented.
To find compounds based on their properties and structural similarity to known compounds:
To quickly find compounds sorted by classes and sub-classes:
Additionally you can find compounds based on their toxicity:
For our top 20 sweeteners use the sweetoscope:
Ahmed J., Preissner S., Dunkel M., Worth C.L., Eckert A, Preissner R. SuperSweet - a resource on natural and artificial sweetening agents.
Nucleic Acids Res. 39 (Database issue 2011) NAR
The sweet taste receptor (SR) is a G protein-coupled receptor (GPCR) that is similar to the dimeric mGluR1 rececptor. Both of these receptors are class C GPCRs, which includes other taste receptors, pheromone receptors, the calcium sensing receptor and the gamma-aminobutyric acid type B receptor. All of these GPCRs have a domain made up of seven transmembrane helices and a large extracellular domain comprising a Venus fly trap domain (VFTD) containing the binding site for ligands and a cysteine-rich domain.