|Recommended name:||Transient receptor potential cation channel subfamily A member 1|
|Sequence length:||1119 AA.|
|Enzyme regulation:||Inhibited by ruthenium red, a potent blocker of TRPV channels|
Recent studies identified various natural transient receptor potential cation channel subfamily A member 1 (TRPA1) agonists.
TRPA1 is also essential for chemical sensing of oxidants and electrophilic agents in the airways. There is some evidence that TRPA1 reacts similar to a reactive airway irritant receptor. TRPA1 is permeable to calcium ions and blocked by ruthenium red, which is known to antagonize bronchoconstriction. It has also been found, that a pretreatment with capsaicin renders C-fibers insensitive to mustard oil, as well as chemical airway irritants. Mustard oil, which is the pungent ingredient in wasabi, is a potent upper airway irritant. Acrolein, methacrolein, methyl vinyl ketone, hypochlorite, and crotone aldehyde are also activators of TRPA1.