|Recommended name:||Potassium channel subfamily K member 2|
|Sequence length:||426 AA.|
The potassium channel, subfamily K, member 2 is a channel protein encoded by the KCNK2 gene. In small diameter sensory neurons TREK1 is often co-expressed with TRPV1.
TREK-1 is formed by two homodimers, which lead potassium into the cell and therefore
control the resting membrane potential. The carboxyl and amino termini are located
at the intracellular site. It can be activated by certain anesthetics, membrane
stretching, intracellular acidosis, heat or phospholipids, such as
phosphatidylinositol. Because of its contribution to physiological,
pathophysiological, and pharmacological processes, TREK-1 has a crucial role in the
therapy of epilepsy, as well as brain and spinal chord ischemia. It is also been
shown that membrane phospholipids like PIP2 control channel gating of TREK-1. If
sensory neurons are stimulated with heat, the co-expression with TRPV1 leads to a
modulation of TRPV1 activity therefore is an interesting target for pain management.
These models are based on different template structures, which show sequence similarity to TREK-1.