SuperPain is a database for pain stimulating and pain relieving compounds, which bind or potentially bind to ion channels, such as TRPV1, TRPM8, TRPA1, hERG, TREK1, P2X, ASIC or voltage-gated sodium channels.
The database consists of about 8,700 ligands, which are characterized by experimentally measured binding affinities. Additionally, 100,000 putative ligands are included.
SuperPain - a resource on pain-relieving compounds targeting ion channels B. O. Gohlke, R. Preissner and S. Preissner Nucleic Acids Res.(Database issue)
It is easy to perform a live search for potential pain relieving compounds. Special features like receptor affinities, half maximal inhibitory concentration or purchasability can be selected and a similarity search can be done.
Currently, there is no experimental data (X-ray, NMR) available on the atomic structure of the different ion channels. Click on Receptor. If Java is installed, you can easily navigate through a homology model of the TRPV1 receptor. Additionally we provide information on the other channels.
Ligands were clustered regarding their similarity to each other and resulted in 684 clusters. Similarities are displayed in an interactive heat-map.