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In order to fit a peptidomimetic compound into a peptide or protein structure, you can load own
strutures into SuperMimic (proteins or peptides should be in PDB format; small molecules should be
in MDL mol or sd file format, the latter providing several conformers and thus enlarging the search space).
On the other hand, you can utilise the provided structure libraries:
Peptide mimetic libraries
About 100 peptidomimetic compounds have been collected from the literature and have been arranged
in sublibraries for alpha-helix-, beta-strand-,
gamma-turn-, beta-turn-mimetics.
The respective pages under 'Libraries/mimetics' show a picture of each structure, give the library
name which is used for it
as well as the chemical name and some information about the usage of the substance described in the
literature. Each structure is linked to the literature references
it was extracted from.
Additionally, the library contains a collection of peptides, consisting of a sequence of a
D-amino acid flanked by two L-amino acids, that can be used as
beta- or gamma-turn mimetics and some peptidomimetic ligands
extracted from the PDB.
Other peptide mimetics with known inhibition functions (like thrombin inhibitors),
which could not be assigned to one of the previous groups, are classified as
drug-like mimetics.
In order to account for the flexibility of the peptide mimetics, each structure is represented
by five to 13 low-energy conformers.
Protein libraries
Insertion of peptide mimetics into proteins is realised by chemical syntheses.
Such syntheses are mostly practised with small proteins.
To allow for rapid and easy identification of candidates for synthesis,
the program is linked to a library of small proteins.
It contains 10403 chains of PDB structures
of at most 100 amino acids length.
Alternatively, this large database can be replaced by a set of 2206 chains with less than 90%
sequence homology, represented by structures with best resolution.
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