gamma-turn-mimetics

(2R)-2-[6-((1S)-1-aminoethyl)(2S,6S)-2-methyl-3-oxomorpholin-4-yl]propanoic acid GT-1 inverse gamma-turn Brickmann(1999) (2R)-2-[6-((1S)-1-aminoethyl)(2S,6R)-2-methyl-3-oxomorpholin-4-yl]propanoic acid GT-2 classical gamma-turn Brickmann(1999) 2-[(6R)-4-(aminomethyl)-5,7-dioxo-1-phenyl-1,4-diazaperhydroepin-6-yl]acetic acid GT-3 heterocyclic y-turn mimetic - based on a 7-membered ring Callahan(1992) (2S)-2-[(3S)-5-((1S)-1-aminoethyl)-3-methyl(2,3-dihydro-6H,7H-1,4-diazepinyl)]propane-1,1-diol GT-4 heterocyclic y-turn mimetic- azepine based Callahan(1993) (3S)-5-((1S)-1-aminoethyl)-1-((1S)-2,2-dihydroxy-isopropyl)-3-methyl-3H,6H,7H-1,4-diazepin-2-one GT-5 heterocyclic y-turn mimetic- azepine based Callahan(1993)Schmidt(1997) 2-[(2S)-3-oxo-4-(2-phenylethyl)-1H,2H,5H-benzo[f]1,4-diazaperhydroepin-2-yl]acetic acid GT-6 heterocyclic y-turn mimetic - based on a 7-membered ring Keenan(1999) (2S)-2-[7-((1S,2S)-1-amino-1,2-dimethylbutyl)(2S,7S)-2-(2-methylpropyl)-3,6-dioxo(1,4,5-oxadiazaperhydroepin-4-yl)]-4-methylpentanoic acid GT-7a heterocyclic y-turn mimetic - based on a 7-membered ring Ferguson(1997) (2S)-2-[7-((1S,2S)-1-amino-1,2-dimethylbutyl)(2S,7S)-2-(2-methylpropyl)-3,6-dioxo(1,4,5-oxadiazaperhydroepin-4-yl)]-4-methylpentanoic acid GT-7b heterocyclic y-turn mimetic - based on a 7-membered ring Ferguson(1997) methyl 2-((3R)-2-oxo-3-{[benzylamino]methyl}piperidyl)acetate GT-8 heterocyclic y-turn mimetic Sato(1992) (1S,3S,5R)-5-[(4-hydroxyphenyl)methyl]-3-(triaminomethyl)cyclohexanecarboxylic acid GT-9 heterocyclic y-turn mimetic Sato(1992) 2-{(4S)-7-amino-4-[(4-hydroxyphenyl)methyl]-3-oxo(2-1,2,4-trihydroisoquinolyl)}(2S,3R)-3-methylpentanoic acid GT-10 heterocyclic y-turn mimetic Schmidt(1997) (9S,1R,6R)-6-amino-2,2,5,5,9-pentamethyl-7,10-dioxo-3,4-dithia-8,11-diazacycloundecanecarboxylic acid GT-11 induced y-turn mimetic - based on side-chain covalent linkage Kishore(1985) (7S,15S,9aR)-9,14-dioxo-15-[(2-oxoethyl)amino]-6,7,8,13,15,21,9a-heptahydroindeno[2,3-a]indeno[3,2-k]pyrrolidino[2,1-g][13]annulene-7-carboxylic acid GT-12 induced y-turn mimetic - based on side-chain covalent linkage Stachel(1998) 2-[(1S)-1-(6-methyl(2-pyridyl))ethyl]-6-methylphenol GT-13 induced y-turn mimetic - based hydrogen bond Lindvall(1999)