Create network by loading a previously stored network
Create network by loading all drugs that belong to one ATC-class
Click on a -sign to expand the corresponding ATC-classification. Click on an ATC-Code to load all drugs belonging to this class as a new network.
Drugs, Targets and Side Effects are shown as nodes in a network. The interactions between these different entities are schown by differently coloured edges. The network can
be explored interactively by double-clicking on nodes directly in the network and by the use of a side-bar with context-sensitive options.
Create a new Network
There are three ways to create a new network:
Type Uniprot- and PubChem-Ids of molecules in the respective boxes, then click "Search". Multiple Ids of the same kind have to be seperated by a semicolon.
Upload a file containing an xml-representation of the network. The xml-representation must have been saved previously using the "Save network as xml" button.
Open the ATC-Tree, then select the classification you are interested in. This will load all drugs with this ATC-classification plus their interactions in the network.
Three different kinds of nodes may be present in the network, distinguishable by their icons:
Human targets (with/without known structure)
Nonhuman targets (with/without known structure)
Interactions between the different kinds of nodes are represented by edges that are coloured according to which kind of nodes they connect:
Drug - Drug
Drug - Human target
Drug - Nonhuman target
Drug - Side Effect
Human target - Human target
Human target - Human target (complex)
Any selected interaction
Functions in the applet
Select a node or edge to get the context-sensitive sidebar displayed
Left click on the node or edge
Select multiple nodes
Press CTRL while clicking on the nodes
Drag a node around
Left click on a node and keep the mouse button pressed, then move the mouse around
Load a nodes interaction partners into the network
Double-click on the node
Delete a node from the network
Right click on the node while pressing SHIFT
Zoom the network
Use the zoom slider at top of the applet
Pan the network
Keep the right mouse button pressed and move the mouse around
Stop the drugs and targets from moving around
Left click on the "FIX NODES"-button. Click again to release them
Fix one node
Select the node, then press SPACE
Alter the edge lengths
Use the edge-length slider at top of the applet
Click on the buttons "HIDE ..." to hide the respective kind of nodes
Change the appearance of the network
Use the three knobs in the upper left of the applet
Increase the speed of the visualisation
Klick on the "FASTER"-button
The context-sensitive sidebar
Adds neighbour proteins, drugs or side-effects to the chosen entity. A maximum of 20 entities of each category can be added at once.
Removes the chosen entity from the network. Note that deleting nodes from the network causes neighbors of the deleted node to float away. To circumvent this effect the user can simply hide and unhide nodes.
By clicking on this option a new tab with the drug or target detail site respectively is open.
Drugs with predicted similar action are loaded into the network. The drugs are fetched from SuperPred a group own drug-target prediction server.
By clicking on this option all drugs belonging to the same ATC class as the chosen drug are highlighted in the network.
To have a first insight into the
For first insights of graph theoretical analysis basic average graph properties (Betweensess, Degree, Clustering Coefficient) for the current and the overall network are calculated.
Displays a list of drugs which are known to cause the chosen side effect.
Displays a list of drugs which share side-effects with the chosen drug, ranked by the number of shared side-effect.